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1. WO2022074402 - NANOPARTICLE FOR ANTI-CANCER PEPTIDES AND USES THEREOF

Publication Number WO/2022/074402
Publication Date 14.04.2022
International Application No. PCT/GB2021/052621
International Filing Date 11.10.2021
IPC
C07K 17/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
17Carrier-bound or immobilised peptides; Preparation thereof
02Peptides being immobilised on, or in, an organic carrier
08the carrier being a synthetic polymer
B82Y 5/00 2011.1
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
5Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 47/60 2017.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 38/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61K 9/5153
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
513Organic macromolecular compounds; Dendrimers
5146obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
5153Polyesters, e.g. poly(lactide-co-glycolide)
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
C07K 17/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
17Carrier-bound or immobilised peptides
02Peptides being immobilised on, or in, an organic carrier
08the carrier being a synthetic polymer
Applicants
  • KING'S COLLEGE LONDON [GB]/[GB]
  • ACADEMIA SINICA [CN]/[CN]
Inventors
  • ULMSCHNEIDER, Martin Bernhard
  • CHEN, Charles Huang
  • HU, Che-Ming Jack
  • LIU, Yu-Han
Agents
  • WITHERS & ROGERS LLP
Priority Data
2016022.209.10.2020GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NANOPARTICLE FOR ANTI-CANCER PEPTIDES AND USES THEREOF
(FR) NANOPARTICULE POUR PEPTIDES ANTICANCÉREUX ET SES UTILISATIONS
Abstract
(EN) There is described a nanoparticle comprising one or more peptides having a sequence comprising the motif GLLxLLxLLLxAAG, wherein each x is independently selected from arginine (R), histidine (H), lysine (K), aspartic acid (D) or glutamic acid (E). Also described is a pharmaceutically acceptable composition comprising the nanoparticle and one or more pharmaceutically acceptable excipients, for use in the treatment of cancer. In addition, there is described a method of treatment of cancer involving administering the pharmaceutically acceptable composition to a patient with cancer, and a kit for treating or preventing cancer comprising the pharmaceutically acceptable composition.
(FR) L'invention concerne une nanoparticule comprenant un ou plusieurs peptides ayant une séquence comprenant le motif GLLxLLxLLLxAAG, chaque x étant indépendamment choisi parmi l'arginine (R), l'histidine (H), la lysine (K), l'acide aspartique (D) ou l'acide glutamique (E). L'invention concerne également une composition pharmaceutiquement acceptable comprenant la nanoparticule et un ou plusieurs excipients pharmaceutiquement acceptables, destinée à être utilisée dans le traitement du cancer. De plus, l'invention concerne une méthode de traitement du cancer impliquant l'administration de la composition pharmaceutiquement acceptable à un patient atteint d'un cancer, et un kit pour le traitement ou la prévention du cancer comprenant la composition pharmaceutiquement acceptable.
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