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1. WO2022072634 - BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER

Publication Number WO/2022/072634
Publication Date 07.04.2022
International Application No. PCT/US2021/052878
International Filing Date 30.09.2021
IPC
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/4985 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • SCORPION THERAPEUTICS, INC. [US]/[US]
Inventors
  • MILGRAM, Benjamin C.
  • ST. JEAN, JR., David
  • WHITE, Ryan D.
  • GUZMAN-PEREZ, Angel
Agents
  • KENDALL, John T.
  • MEIKLEJOHN, Anita L.
Priority Data
63/085,68630.09.2020US
63/143,44229.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BICYCLIC COMPOUNDS FOR USE IN THE TREATMENT CANCER
(FR) COMPOSÉS BICYCLIQUES DESTINÉS À ÊTRE UTILISÉS DANS LE TRAITEMENT DU CANCER
Abstract
(EN) This disclosure provides chemical entities (e.g., a compound or a pharmaceutically acceptable salt, and/or hydrate, and/or cocrystal, and/or drug combination of the compound) that inhibit epidermal growth factor receptor (EGFR, ERBB1) and/or Human epidermal growth factor receptor 2 (HER2, ERBB2). These chemical entities are useful, e.g., for treating a condition, disease or disorder in which increased (e.g., excessive) EGFR and/or HER2 activation contributes to the pathology and/or symptoms and/or progression of the condition, disease or disorder (e.g., cancer) in a subject (e.g., a human). This disclosure also provides compositions containing the same as well as methods of using and making the same.
(FR) La présente divulgation concerne des entités chimiques (par exemple, un composé ou un sel pharmaceutiquement acceptables, et/ou un hydrate, et/ou un co-cristal, et/ou une combinaison de médicaments du composé) qui inhibent le récepteur du facteur de croissance épidermique (EGFR, ERBB1) et/ou le récepteur 2 du facteur de croissance épidermique (HER2, ERBB2). Les entités chimiques de la présente divulgation sont utiles, par exemple, pour traiter une affection, une maladie ou un trouble dans lequel une activation accrue (par exemple, excessive) de EGFR et/ou de HER2 contribue à la pathologie et/ou aux symptômes et/ou à la progression de l'affection, de la maladie ou du trouble (par exemple, un cancer) chez un sujet (par exemple, un être humain). La présente divulgation concerne également des compositions les contenant, ainsi que des procédés d'utilisation et de fabrication de celles-ci.
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