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1. WO2022071559 - ONCOLYTIC VACCINIA VIRUS HAVING LONG GENE DELETION

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Publication Number WO/2022/071559
Publication Date 07.04.2022
International Application No. PCT/JP2021/036371
International Filing Date 01.10.2021
IPC
C12N 7/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
A61K 35/768 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
768Oncolytic viruses not provided for in groups A61K35/761-A61K35/76697
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61K 35/76
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
A61K 35/768
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
768Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • 国立大学法人鳥取大学 NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY [JP]/[JP]
  • 株式会社エボルブ・バイオセラピューティクス EVOLVE BIOTHERAPEUTICS CO., LTD. [JP]/[JP]
Inventors
  • 中村　貴史 NAKAMURA Takafumi
  • 桑野　望 KUWANO Nozomi
  • 中武　大夢 NAKATAKE Motomu
  • 河野　博通 KOUNO Hiromichi
Agents
  • 特許業務法人平木国際特許事務所 HIRAKI & ASSOCIATES
Priority Data
2020-16666101.10.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) ONCOLYTIC VACCINIA VIRUS HAVING LONG GENE DELETION
(FR) VIRUS DE LA VACCINE ONCOLYTIQUE AYANT UNE LONGUE DÉLÉTION DE GÈNE
(JA) 広範囲遺伝子欠損を有する腫瘍溶解性ワクシニアウイルス
Abstract
(EN) Provided are: a vaccinia virus which can be proliferated specifically in a cancer cell to injure the cancer cell; and a use of the virus in a cancer therapy.　This vaccinia virus is an oncolytic vaccinia virus in which a region composed of 7000 to 9000 base pairs contained in the genome sequence for the vaccinia virus is deleted so that the vaccinia virus cannot proliferate in a normal cell but can proliferate specifically in a cancer cell to injure the cancer cell specifically.
(FR) L'invention concerne : un virus de la vaccine qui peut être amené à proliférer spécifiquement dans une cellule cancéreuse pour attaquer la cellule cancéreuse; et une utilisation du virus dans une thérapie anticancéreuse.　Ce virus de la vaccine est un virus de la vaccine oncolytique dans lequel une région composée de 7000 à 9000 paires de bases contenues dans la séquence génomique pour le virus de la vaccine est supprimée de telle sorte que le virus de la vaccine ne peut pas proliférer dans une cellule normale mais peut proliférer spécifiquement dans une cellule cancéreuse pour blesser la cellule cancéreuse spécifiquement.
(JA) 癌細胞において特異的に増殖し、癌細胞を障害するワクシニアウイルスの提供及び該ウイルスの癌治療への利用の提供。　ワクシニアウイルスのゲノム配列の7000～9000塩基からなる領域が欠損しており、正常細胞内では増殖しないが、癌細胞内で特異的に増殖し、癌細胞を特異的に障害する腫瘍溶解性を有するワクシニアウイルス。
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