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1. WO2022051727 - BICISTRONIC INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR)/ACTIVATING CHIMERIC ANTIGEN RECEPTOR (aCAR) CONSTRUCTS FOR USE IN CANCER THERAPIES

Publication Number WO/2022/051727
Publication Date 10.03.2022
International Application No. PCT/US2021/049315
International Filing Date 07.09.2021
IPC
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
C12N 15/11
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
Applicants
  • IMMPACT-BIO LTD. [IL]/[IL]
  • KENDALL, Rick [US]/[US]
  • CALZONE, Frank [US]/[US]
  • FOORD, Orit [US]/[US]
  • ADAMS, Gregor B. [US]/[US]
  • KIM, Tanya [US]/[US]
  • BASSAN, David [IL]/[IL]
Inventors
  • KENDALL, Rick
  • CALZONE, Frank
  • FOORD, Orit
  • ADAMS, Gregor B.
  • KIM, Tanya
  • BASSAN, David
  • YI, Jason
  • SHARBI-YUNGER, Adi
Agents
  • MACDOUGALL, Christina A.
  • ANTCZAK, Andrew, J.
  • BALL, Conor, S.
  • KWAK, Byung, Cheol
  • ESKER, Todd
Priority Data
63/074,81204.09.2020US
63/178,45222.04.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BICISTRONIC INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR)/ACTIVATING CHIMERIC ANTIGEN RECEPTOR (aCAR) CONSTRUCTS FOR USE IN CANCER THERAPIES
(FR) CONSTRUCTIONS DE RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE INHIBITEUR (ICAR)/RÉCEPTEUR ANTIGÉNIQUE ACTIVATEUR (ACAR) DESTINÉES À ÊTRE UTILISÉES EN THÉRAPIES ANTICANCÉREUSES
Abstract
(EN) The invention relates to the field of cancer immunotherapy by employing bicistronic inhibitory chimeric antigen receptor (iCAR)/ activating chimeric antigen receptor (aCAR) constructs for use in cancer treatment therapies.
(FR) L'invention concerne le domaine de l'immunothérapie anticancéreuse en employant des constructions de récepteur antigénique chimérique inhibiteur bicistronique (iC AR)/récepteur antigénique chimérique activateur (aCAR) destinées à être utilisées dans des thérapies de traitement du cancer.
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