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1. WO2022051060 - CROSSLINKING OF NON-ANIMAL-DERIVED HYALURONIC ACID WITH DIVINYL SULFONE

Publication Number WO/2022/051060
Publication Date 10.03.2022
International Application No. PCT/US2021/045150
International Filing Date 09.08.2021
IPC
A61K 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
C08B 37/08 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
08Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
CPC
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
C08B 37/003
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
0024beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
00272-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
003Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
Applicants
  • ORTHOGENRX, INC. [US]/[US]
Inventors
  • MENCEL, James, J.
  • TOLEDO-VELASQUEZ, David
  • DALEY, Michael, Joseph
Agents
  • TSEVDOS, Estelle, J.
Priority Data
63/073,06401.09.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CROSSLINKING OF NON-ANIMAL-DERIVED HYALURONIC ACID WITH DIVINYL SULFONE
(FR) RÉTICULATION D'ACIDE HYALURONIQUE NON DÉRIVÉ D'ANIMAL AVEC DE LA DIVINYLSULFONE
Abstract
(EN) The present invention provides a non-animal derived, such as non-avian derived hyaluronic acid (HA) that has a molecular weight of about 500 to about 16000 kD, preferably about 500 kDa to about 10000 kDa. Most preferred HAs have a molecular weight of about 3000 kDa to about 6000 kDa. This HA is DVS cross-linked, water soluble and stable over time. The presently provided HA is free from the immunogenic proteins that are found in animal derived HAs. Further, the HAs of the present invention are microbiologically-derived or chemically synthesized, yet cross-linked to remain water soluble and stable over a period of time. Preparation of cross-linked HA' s of the invention using non-animal derived HA avoids the negative immunologic reactions observed for previously described animal derived cross -linked HAs.
(FR) La présente invention concerne un acide hyaluronique (HA) non dérivé d'un animal, tel que non dérivé d'oiseaux, qui a un poids moléculaire d'environ 500 à environ 16 000 kD, de préférence d'environ 500 kDa à environ 10 000 kDa. Les HA idéalement préférés ont un poids moléculaire d'environ 3 000 kDa à environ 6 000 kDa. Ce HA est réticulé avec de la DVS, est hydrosoluble et est stable dans le temps. Le HA selon la présente invention est exempt des protéines immunogènes qui sont trouvées dans des HA dérivés d'animaux. En outre, les HA de la présente invention sont microbiologiquement dérivés ou chimiquement synthétisés, mais encore réticulés pour demeurer hydrosolubles et stables sur une certaine période de temps. La préparation de HA réticulés de l'invention à l'aide d'un HA non dérivé d'un animal évite les réactions immunologiques négatives observées pour des HA réticulés dérivés d'animal préalablement décrits.
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