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1. WO2022049534 - POLYMORPHIC FORMS OF A RORΓ INHIBITING COMPOUND AND PROCESSES FOR ITS PREPARATION

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Publication Number WO/2022/049534
Publication Date 10.03.2022
International Application No. PCT/IB2021/058060
International Filing Date 03.09.2021
IPC
C07D 241/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
A61K 31/495 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
C07D 241/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applicants
  • GLENMARK SPECIALTY S.A. [CH]/[CH]
Inventors
  • DAS, Sanjib
  • CHAUDHARI, Sachin Sundarlal
  • GHARAT, Laxmikant Atmaram
  • KADAM, Suresh Mahadev
  • GAVHANE, Sachin
  • KANSAGRA, Bipin Parsottam
  • PAWASE, Shailesh Shrirang
  • BHUJBAL, Anil Subhash
  • PATIL, Ulhas Digambar
  • NIRGUDE, Sunil Pandurang
Priority Data
20202103795603.09.2020IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) POLYMORPHIC FORMS OF A RORΓ INHIBITING COMPOUND AND PROCESSES FOR ITS PREPARATION
(FR) FORMES POLYMORPHES D'UN COMPOSÉ INHIBITEUR DE RORΓ ET LEURS PROCÉDÉS DE PRÉPARATION
Abstract
(EN) The present invention is directed to solid state forms of a compound which has retinoid-related orphan receptor gamma (RORy) modulator activity. Particularly the present invention relates to solid state forms of the compound (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl) acetamide, processes for their preparation, pharmaceutical compositions containing the same and their use in therapy. More, particularly the present invention relates to crystalline form of the compound (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)phenyl)-N-(4-(3-(2-ethylphenyl)pyrazin-2-yl)phenyl)acetamide, processes for their preparation, pharmaceutical compositions containing the same and their use in therapy.
(FR) La présente invention concerne des formes à l'état solide d'un composé qui a une activité de modulateur du récepteur gamma orphelin associé au rétinoïde (RORy). En particulier, la présente invention concerne des formes à l'état solide du composé (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)) phényle)-N-(4-(3-(2-éthylphényl)pyrazin-2-yl) phényl)acétamide, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie. Plus particulièrement, la présente invention concerne une forme cristalline du composé (S)-2-(4-(1,1-difluoro-2-hydroxypropyl)) phényle)-N- (4-(3-(2-éthylphényl)pyrazin-2-yl)phényl)acétamide, des procédés pour leur préparation, des compositions pharmaceutiques les contenant et leur utilisation en thérapie.
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