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1. WO2022046633 - COVID-19 VACCINES WITH TOCOPHEROL-CONTAINING SQUALENE EMULSION ADJUVANTS

Publication Number WO/2022/046633
Publication Date 03.03.2022
International Application No. PCT/US2021/047149
International Filing Date 23.08.2021
IPC
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 2039/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
53DNA (RNA) vaccination
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 2039/55511
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
A61K 2039/55555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
A61K 2039/55566
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55566Emulsions, e.g. Freund's adjuvant, MF59
A61K 2039/57
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
57characterised by the type of response, e.g. Th1, Th2
Applicants
  • SANOFI PASTEUR INC. [US]/[US]
  • GLAXOSMITHKLINE BIOLOGICALS SA [BE]/[BE]
Inventors
  • ANOSOVA, Natalie
  • AUSAR, Salvador Fernando
  • BERRY, Catherine
  • BOUDET, Florence
  • BREUER, Thomas
  • CASIMIRO, Danilo
  • CHICZ, Roman M.
  • DAYAN, Gustavo
  • DE BRUYN, Guy
  • DIAZGRANADOS, Carlos
  • FU, Tong-Ming
  • GARINOT, Marie
  • GRADY, Lorry
  • GURUNATHAN, Sanjay
  • KALNIN, Kirill
  • KHRAMTSOV, Nikolai
  • LECOUTURIER, Valérie
  • RAHMAN, Nausheen
  • RUIZ, Sophie
  • SAVARINO, Stephen
  • SRIDHAR, Saranya
  • SRIVASTAVA, Indresh K.
  • TARTAGLIA, James
  • TIBBITTS, Timothy
Agents
  • LI, Z. Ying
  • ALVAREZ, Mauricio
  • CAIANIELLO, David
  • CHATTERJEE, Debashree
  • LEE, Wyan-Ching M.
  • VOGEL, Ron
Priority Data
63/069,17124.08.2020US
63/184,15504.05.2021US
63/189,04414.05.2021US
63/215,09225.06.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COVID-19 VACCINES WITH TOCOPHEROL-CONTAINING SQUALENE EMULSION ADJUVANTS
(FR) VACCINS CONTRE LA COVID-19 AVEC DES ADJUVANTS D'ÉMULSION DE SQUALÈNE CONTENANT DU TOCOPHÉROL
Abstract
(EN) Provided are novel vaccines for prophylactic treatment of SARS-CoV-2 infections and COVID-19 and methods of making the vaccines, wherein the vaccines contain an oil-in-water emulsion comprising tocopherol and squalene.
(FR) L'invention concerne de nouveaux vaccins pour le traitement prophylactique des infections par le SARS-CoV-2 et la COVID-19 et des procédés de fabrication desdits vaccins, les vaccins contenant une émulsion huile dans l'eau comprenant du tocophérol et du squalène.
Latest bibliographic data on file with the International Bureau