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1. WO2022043465 - INHIBITORS OF NO PRODUCTION

Publication Number WO/2022/043465
Publication Date 03.03.2022
International Application No. PCT/EP2021/073663
International Filing Date 26.08.2021
IPC
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 27/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
C07K 5/078 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
078the first amino acid being heterocyclic, e.g. Pro, His, Trp
CPC
A61P 27/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07K 5/06165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06139with the first amino acid being heterocyclic
06165and Pro-amino acid; Derivatives thereof
Applicants
  • MAX DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT [DE]/[DE]
  • CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN [DE]/[DE]
  • FORSCHUNGSVERBUND BERLIN E.V. [DE]/[DE]
Inventors
  • KETTENMANN, Helmut
  • WOLF, Susanne
  • JORDAN, Philipp
  • KLEISSLE, Sabrina
  • NEUENSCHWANDER, Martin
  • SPECKER, Edgar
  • NAZARE, Marc
Agents
  • RÖHLK, Christian
Priority Data
20192972.626.08.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF NO PRODUCTION
(FR) INHIBITEURS DE LA PRODUCTION DE NO
Abstract
(EN) The invention relates to compounds useful as inhibitors of NO production, especially inhibitors of the inducible NO synthase iNOS expressed by microglia and macrophages. The invention also relates to pharmaceutical compositions comprising these compounds and to therapeutic uses of these compounds, especially in the prophylaxis or treatment of conditions characterized by excess NO production, such as ischemic stroke and retinopathies.
(FR) L'invention concerne des composés utiles en tant qu'inhibiteurs de la production de NO, en particulier des inhibiteurs de la NO synthase inductible, iNOS, exprimée par une microglie et des macrophages. L'invention concerne également des compositions pharmaceutiques comprenant ces composés et des utilisations thérapeutiques de ces composés, en particulier dans la prophylaxie ou le traitement d'états caractérisés par une production excessive de NO, comme un accident ischémique cérébral et des rétinopathies.
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