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1. WO2022043374 - AMINOCARBAMOYL COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS

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Publication Number WO/2022/043374
Publication Date 03.03.2022
International Application No. PCT/EP2021/073503
International Filing Date 25.08.2021
IPC
C07C 243/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
243Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
26with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
28to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
C07C 271/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06Esters of carbamic acids
08having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
C07C 311/13 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
01Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
12of an unsaturated carbon skeleton containing rings
13the carbon skeleton containing six-membered aromatic rings
C07D 207/26 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
18having one double bond between ring members or between a ring member and a non-ring member
22with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24Oxygen or sulfur atoms
262-Pyrrolidones
C07D 211/76 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68having one double bond between ring members or between a ring member and a non-ring member
72with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74Oxygen atoms
76attached in position 2 or 6
C07D 231/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
CPC
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07C 243/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
243Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
26with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
28to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
C07C 243/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
243Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
24Hydrazines having nitrogen atoms of hydrazine groups acylated by carboxylic acids
26with acylating carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
34to carbon atoms of a carbon skeleton further substituted by nitrogen atoms
C07C 2601/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
02with a three-membered ring
C07C 2601/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
06with a five-membered ring
08the ring being saturated
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JO, JP, KE, KG, KH, KM, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, WS, ZA, ZM, ZW)
  • HOFFMANN-LA ROCHE INC. [US]/[US] (US)
Inventors
  • CHEN, Jianguo
  • LIANG, Chungen
  • MIAO, Kun
  • WU, Yao
  • YUN, Hongying
  • ZHANG, Weixing
Agents
  • NEUHAUS, Christian
Priority Data
PCT/CN2020/11185227.08.2020CN
PCT/CN2021/10867627.07.2021CN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) AMINOCARBAMOYL COMPOUNDS FOR THE TREATMENT OF VIRAL INFECTIONS
(FR) COMPOSÉS AMINOCARBAMOYLE DESTINÉS AU TRAITEMENT D'INFECTIONS VIRALES
front page image
Abstract
(EN) The present invention relates to compounds of formula (II) wherein R1-R5, X and L are as described herein, and pharmaceutically acceptable salts thereof, compositions including the compounds and methods of using the compounds, particularly in the treatment and prophylaxis of coronavirus infection.
(FR) La présente invention concerne des composés de formule (II), dans laquelle R1 à R5, X et L sont tels que décrits dans la description, et leurs sels pharmaceutiquement acceptables, ainsi que des compositions comprenant les composés et des méthodes d'utilisation des composés, notamment dans le traitement et la prophylaxie d'une infection par le coronavirus.
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