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1. WO2022043120 - PREDICTION OF A RESPONSE OF A PROSTATE CANCER SUBJECT TO RADIOTHERAPY BASED ON PDE4D7 CORRELATED GENES

Publication Number WO/2022/043120
Publication Date 03.03.2022
International Application No. PCT/EP2021/072774
International Filing Date 17.08.2021
IPC
C12Q 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/106
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12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • KONINKLIJKE PHILIPS N.V. [NL]/[NL]
Inventors
  • HOFFMANN, Ralf, Dieter
  • STOFFELS, Monique
Agents
  • PHILIPS INTELLECTUAL PROPERTY & STANDARDS
Priority Data
20193628.331.08.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PREDICTION OF A RESPONSE OF A PROSTATE CANCER SUBJECT TO RADIOTHERAPY BASED ON PDE4D7 CORRELATED GENES
(FR) PRÉDICTION D'UNE RÉPONSE D'UN SUJET ATTEINT D'UN CANCER DE LA PROSTATE À UNE RADIOTHÉRAPIE BASÉE SUR DES GÈNES CORRÉLÉS À PDE4D7
Abstract
(EN) The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of two or more PDE4D7 correlated genes selected from the group consisting of: ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1, and VWA2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the 5 prediction of the radiotherapy response based on the gene expression profiles for the two or more PDE4D7 correlated genes.
(FR) L'invention concerne un procédé de prédiction d'une réponse d'un sujet atteint d'un cancer de la prostate à une radiothérapie, comprenant la détermination ou la réception du résultat d'une détermination d'un profil d'expression génique pour chacun des deux gènes corrélés à PDE4D7 ou plus sélectionnés dans le groupe constitué par : ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1 et VWA2, lesdits profils d'expression génique étant déterminés dans un échantillon biologique obtenu à partir du sujet, ainsi que la détermination de la prédiction de la réponse à la radiothérapie sur la base des profils d'expression génique pour les deux gènes corrélés à PDE4D7 ou plus.
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