WO2022043120 PREDICTION OF A RESPONSE OF A PROSTATE CANCER SUBJECT TO RADIOTHERAPY BASED ON PDE4D7 CORRELATED GENES

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Publication Number WO/2022/043120

Publication Date 03.03.2022

International Application No. PCT/EP2021/072774

International Filing Date 17.08.2021

IPC

CPC

Applicants

KONINKLIJKE PHILIPS N.V. [NL]/[NL]

Inventors

HOFFMANN, Ralf, Dieter
STOFFELS, Monique

Agents

PHILIPS INTELLECTUAL PROPERTY & STANDARDS

Priority Data

20193628.3

31.08.2020

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) PREDICTION OF A RESPONSE OF A PROSTATE CANCER SUBJECT TO RADIOTHERAPY BASED ON PDE4D7 CORRELATED GENES

(FR) PRÉDICTION D'UNE RÉPONSE D'UN SUJET ATTEINT D'UN CANCER DE LA PROSTATE À UNE RADIOTHÉRAPIE BASÉE SUR DES GÈNES CORRÉLÉS À PDE4D7

Abstract

(EN) The invention relates to a method of predicting a response of a prostate cancer subject to radiotherapy, comprising determining or receiving the result of a determination of a gene expression profile for each of two or more PDE4D7 correlated genes selected from the group consisting of: ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1, and VWA2, said gene expression profiles being determined in a biological sample obtained from the subject, and determining the 5 prediction of the radiotherapy response based on the gene expression profiles for the two or more PDE4D7 correlated genes.

(FR) L'invention concerne un procédé de prédiction d'une réponse d'un sujet atteint d'un cancer de la prostate à une radiothérapie, comprenant la détermination ou la réception du résultat d'une détermination d'un profil d'expression génique pour chacun des deux gènes corrélés à PDE4D7 ou plus sélectionnés dans le groupe constitué par : ABCC5, CUX2, KIAA1549, PDE4D, RAP1GAP2, SLC39A11, TDRD1 et VWA2, lesdits profils d'expression génique étant déterminés dans un échantillon biologique obtenu à partir du sujet, ainsi que la détermination de la prédiction de la réponse à la radiothérapie sur la base des profils d'expression génique pour les deux gènes corrélés à PDE4D7 ou plus.

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1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions

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Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions

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Q	MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1	Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68	involving nucleic acids
6876	Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883	for diseases caused by alterations of genetic material
6886	for cancer

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2600	Oligonucleotides characterized by their use
106	Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

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2600	Oligonucleotides characterized by their use
118	Prognosis of disease development

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1. WO2022043120 - PREDICTION OF A RESPONSE OF A PROSTATE CANCER SUBJECT TO RADIOTHERAPY BASED ON PDE4D7 CORRELATED GENES