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1. WO2022041860 - FUNCTIONALIZED SURFACE TREATMENT METHOD FOR USE IN HIGH-THROUGHPUT NUCLEIC ACID IN SITU SYNTHESIS BY 3D INKJET METHOD

Publication Number WO/2022/041860
Publication Date 03.03.2022
International Application No. PCT/CN2021/094309
International Filing Date 18.05.2021
IPC
C08J 7/12 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H142
7Chemical treatment or coating of shaped articles made of macromolecular substances
12Chemical modification
C12P 19/34 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
C12P 19/30 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
26Preparation of nitrogen-containing carbohydrates
28N-glycosides
30Nucleotides
CPC
B29C 64/106
BPERFORMING OPERATIONS; TRANSPORTING
29WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
CSHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
64Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
10Processes of additive manufacturing
106using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
B33Y 10/00
BPERFORMING OPERATIONS; TRANSPORTING
33ADDITIVE MANUFACTURING TECHNOLOGY
YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
10Processes of additive manufacturing
C08J 7/12
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
JWORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G
7Chemical treatment or coating of shaped articles made of macromolecular substances
12Chemical modification
C09C 1/30
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
CTREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES
1Treatment of specific inorganic materials other than fibrous fillers
28Compounds of silicon
30Silicic acid
C09C 3/04
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
CTREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES
3Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
04Physical treatment, e.g. grinding, treatment with ultrasonic vibrations
C09C 3/06
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
CTREATMENT OF INORGANIC MATERIALS, OTHER THAN FIBROUS FILLERS, TO ENHANCE THEIR PIGMENTING OR FILLING PROPERTIES
3Treatment in general of inorganic materials, other than fibrous fillers, to enhance their pigmenting or filling properties
06Treatment with inorganic compounds
Applicants
  • 上海迪赢生物科技有限公司 DYNEGE BIOSCIENCE CORPORATION [CN]/[CN]
Inventors
  • 张满仓 ZHANG, Mancang
  • 王立兵 WANG, Libing
  • 候彩铃 HOU, Cailing
Agents
  • 北京纪凯知识产权代理有限公司 JEEKAI&PARTNERS
Priority Data
202010862060.X25.08.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) FUNCTIONALIZED SURFACE TREATMENT METHOD FOR USE IN HIGH-THROUGHPUT NUCLEIC ACID IN SITU SYNTHESIS BY 3D INKJET METHOD
(FR) PROCÉDÉ DE TRAITEMENT DE SURFACE FONCTIONNALISÉE DESTINÉ À ÊTRE UTILISÉ DANS UNE SYNTHÈSE À HAUT DÉBIT, IN SITU, D'ACIDE NUCLÉIQUE PAR UN PROCÉDÉ À JET D'ENCRE 3D
(ZH) 一种用于3D喷墨法高通量核酸原位合成的功能化表面处理方法
Abstract
(EN) A functionalized surface treatment method for use in high-throughput nucleic acid in situ synthesis by 3D inkjet method, comprising the following steps: performing a hydroxylation enrichment treatment of the surface of a substrate; modifying hydrophobic molecules on the surface of the substrate, the hydrophobic molecules being nonreactive to phosphoramidite monomers; employing a multichannel piezoelectric inkjet nozzle component to spray an ink onto a preset area on the surface of the substrate for microetching, the etching ink being formulated with a fluoride compound that is reactive to the hydrophobic molecules; and modifying hydrophilic molecules on the surface of the substrate.
(FR) L'invention concerne un procédé de traitement de surface fonctionnalisée destiné à être utilisé dans la synthèse à haut débit, in situ, d'acide nucléique par un procédé à jet d'encre 3D comprenant les étapes suivantes, consistant à : réaliser un traitement d'enrichissement par hydroxylation de la surface d'un substrat ; modifier les molécules hydrophobes à la surface du substrat, les molécules hydrophobes étant non réactives vis-à-vis de monomères de phosphoramidite ; utiliser un composant de buse piézoélectrique multicanal à jet d'encre pour pulvériser une encre sur une zone prédéfinie sur la surface du substrat pour une microgravure, l'encre de gravure étant formulée avec un composé de fluorure qui est réactif vis-à-vis des molécules hydrophobes ; et modifier les molécules hydrophiles à la surface du substrat.
(ZH) 一种用于3D喷墨法高通量核酸原位合成的功能化表面处理方法,包括如下步骤:将基底的表面进行富羟基化处理;在基底的表面修饰疏水性分子;疏水性分子不与亚磷酰胺单体反应;采用多通道压电喷墨头组件将蚀刻墨水喷射到基底表面的预设区域进行微蚀刻;蚀刻墨水采用疏水性分子反应的氟盐类化合物配制;在基底的表面修饰亲水性分子。
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