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1. WO2022029813 - GYNAECOLOGICAL COMPOSITIONS BASED ON CANNABIDIOL AND TERPENES IN COMBINATION WITH PERIPHERAL VASODILATORS

Publication Number WO/2022/029813
Publication Date 10.02.2022
International Application No. PCT/IT2021/050241
International Filing Date 03.08.2021
IPC
A61K 31/352 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/01 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
A61P 25/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
22Anxiolytics
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
CPC
A61K 31/01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
A61K 31/015
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/366
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61K 9/0034
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Applicants
  • AGORA' PHARMA S.R.L. [IT]/[IT]
Inventors
  • PELAGATTI, Tommaso
Agents
  • BANCHETTI, Marina
  • BALZANO, Francesca
  • TIBURZI, Andrea
  • SANTI, Filippo
  • GITTO, Serena
  • MULAS, Chiara
  • FERRIERO, Paolo
  • BIONDINI, Daniele
  • CATALDI, Silvia
  • BURCHIELLI, Riccardo
  • DE FILIPPIS, Sara
Priority Data
10202000001895203.08.2020IT
Publication Language English (en)
Filing Language Italian (IT)
Designated States
Title
(EN) GYNAECOLOGICAL COMPOSITIONS BASED ON CANNABIDIOL AND TERPENES IN COMBINATION WITH PERIPHERAL VASODILATORS
(FR) COMPOSITIONS GYNÉCOLOGIQUES À BASE DE CANNABIDIOL ET DE TERPÈNES EN COMBINAISON AVEC DES VASODILATATEURS PÉRIPHÉRIQUES
Abstract
(EN) Compositions based on cannabidiol and one or more of the terpenes contained in Cannabis sativa or in other plant species are provided, in combination with natural peripheral vasodilators. The terpenes are preferably selected from β-myrcene and β-caryophyllene, and are combined with plant active principles with vasodilatory, vasokinetic and/or spasmolytic activity such as coumarins, in particular visnadine and possibly forskolin. The proposed compositions have proven to be able to enhance the activity of cannabidiol, terpenes and peripheral vasodilators in the treatment of various gynaecological conditions, such as vulvar atrophy and vaginal dryness, without causing discomfort or udesired side effects.
(FR) L'invention concerne des compositions à base de cannabidiol et d'un ou de plusieurs des terpènes contenus dans Cannabis sativa ou dans d'autres espèces végétales, en combinaison avec des vasodilatateurs périphériques naturels. Les terpènes sont de préférence choisis parmi le β-myrcène et le β-caryophyllène, et sont combinés avec des principes actifs végétaux présentant une activité vasodilatatrice, vasocinétique et/ou spasmolytique comme les coumarines, en particulier la visnadine et éventuellement la forskoline. Les compositions proposées se sont révélées être aptes à améliorer l'activité du cannabidiol, des terpènes et des vasodilatateurs périphériques dans le traitement de divers états gynécologiques, tels que l'atrophie vulvaire et la sécheresse vaginale, sans provoquer d'inconfort ou d'effets secondaires indésirables.
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