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1. WO2022029459 - SYNTHESIS OF NOVEL IMIPRIDONE DERIVATIVES AND THEIR EVALUATION FOR THEIR ANTICANCER ACTIVITY

Publication Number WO/2022/029459
Publication Date 10.02.2022
International Application No. PCT/HU2021/050047
International Filing Date 05.08.2021
IPC
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61K 31/555 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
555containing heavy metals, e.g. hemin, hematin, melarsoprol
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07F 17/02 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
17Metallocenes
02of metals of Groups 8, 9 or 10 of the Periodic System
C07D 471/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
12in which the condensed system contains three hetero rings
14Ortho-condensed systems
C07F 17/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
17Metallocenes
02of metals of Groups 8, 9 or 10 of the Periodic System
Applicants
  • EÖTVÖS LORÁND TUDOMÁNYEGYETEM [HU]/[HU]
  • SEMMELWEIS EGYETEM [HU]/[HU]
Inventors
  • CSÁMPAI, Antal
  • BÁRÁNY, Péter
  • CZUCZI, Tamás
  • KOVÁCS, Imre
  • ADAMIS, Bálint
  • NÉMETH, Zsófia
  • MURÁNYI, József
  • OLÁHNÉ SZABÓ, Rita
  • BŐSZE, Szilvia
  • MEZŐ, Gábor
  • KŐHIDAI, László
  • LAJKÓ, Eszter
  • TAKÁCS, Angéla
  • LÁNG, Orsolya
  • MEZŐ, Diána
Agents
  • MOLNÁR, István
Priority Data
P200025506.08.2020HU
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SYNTHESIS OF NOVEL IMIPRIDONE DERIVATIVES AND THEIR EVALUATION FOR THEIR ANTICANCER ACTIVITY
(FR) SYNTHÈSE DE NOUVEAUX DÉRIVÉS D'IMIPRIDONE ET LEUR ÉVALUATION CONCERNANT LEUR ACTIVITÉ ANTICANCÉREUSE
Abstract
(EN) The present invention relates to compounds of formula (I) (I) or pharmaceutically acceptable salts, and stereoisomers thereof, including enantiomers, racemic mixtures, mixtures of enantiomers, or combinations thereof, which are applicable for use in treating cancer diseases. The present invention further relates to a pharmaceutical composition comprising the above compounds.
(FR) La présente invention concerne des composés de formule (I) (I) ou des sels pharmaceutiquement acceptables, et leurs stéréo-isomères, comprenant des énantiomères, des mélanges racémiques, des mélanges d'énantiomères, ou certaines de leurs combinaisons, qui peuvent être appliqués à des fins d'utilisation dans le traitement de maladies cancéreuses. La présente invention concerne également une composition pharmaceutique comprenant les composés susmentionnés.
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