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1. WO2022029299 - LABORATORY EQUIPMENT, CORRESPONDING USES AND METHODS

Publication Number WO/2022/029299
Publication Date 10.02.2022
International Application No. PCT/EP2021/072026
International Filing Date 06.08.2021
IPC
B01L 3/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01L 9/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
9Supporting devices; Holding devices
CPC
B01L 2200/027
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
02Adapting objects or devices to another
026Fluid interfacing between devices or objects, e.g. connectors, inlet details
027for microfluidic devices
B01L 2200/0605
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0605Metering of fluids
B01L 2200/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
10Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
B01L 2300/047
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
04Closures and closing means
046Function or devices integrated in the closure
047Additional chamber, reservoir
B01L 2300/0645
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0645Electrodes
B01L 2300/087
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0861Configuration of multiple channels and/or chambers in a single devices
087Multiple sequential chambers
Applicants
  • THERMO FISHER SCIENTIFIC GENEART GMBH [DE]/[DE]
Inventors
  • ROMIG, Ansgar
  • LOCHNER, Alexander
  • KHERZNER, Mark
Agents
  • STELLBRINK & PARTNER PATENTANWÄLTE MBB
Priority Data
2012261.006.08.2020GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) LABORATORY EQUIPMENT, CORRESPONDING USES AND METHODS
(FR) ÉQUIPEMENT DE LABORATOIRE, UTILISATIONS ET PROCÉDÉS CORRESPONDANTS
Abstract
(EN) The present invention relates to devices, system and methods for synthesizing and post-processing nucleic acids. The system comprising a fluid supply unit, a synthesis unit comprising a microfluidic chip, configured for the synthesis of nucleic acids, a valve assembly, comprising at least one multiport valve, and a collection unit configured to collect nucleic acids. The method for synthesising nucleic acids utilizes the system and comprises synthesising nucleic acids on the microfluidic chip, selectively releasing synthesised nucleic acids from the microfluidic chip, guiding released nucleic acids to the collection unit, and collecting released nucleic acids in a well plate comprised by the collection unit. The method for post-processing synthesized nucleic acids comprises providing one or more nucleic acids attached to a solid support in a first compartment, adding a first solution to cleave the nucleic acids off the support and adding a second solution to elute the nucleic acids into a second compartment.
(FR) La présente invention concerne des dispositifs, un système et des procédés pour la synthèse et le post-traitement d'acides nucléiques. Le système comprend une unité d'alimentation en fluide, une unité de synthèse comprenant une puce microfluidique, configurée pour la synthèse d'acides nucléiques, un ensemble soupape, comprenant au moins une soupape multi-voies, et une unité de collecte configurée pour la collecte d'acides nucléiques. Le procédé de synthèse d'acides nucléiques utilise le système et comprend la synthèse d'acides nucléiques sur la puce microfluidique, la libération sélective d'acides nucléiques synthétisés à partir de la puce microfluidique, le guidage d'acides nucléiques libérés vers l'unité de collecte, et la collecte d'acides nucléiques libérés dans une plaque de puits constituée par l'unité de collecte. Le procédé de post-traitement d'acides nucléiques synthétisés comprend la fourniture d'un ou de plusieurs acide(s) nucléique(s) fixé(s) à un support solide dans un premier compartiment, l'ajout d'une première solution pour le clivage des acides nucléiques hors du support et l'ajout d'une seconde solution pour l'élution des acides nucléiques dans un second compartiment.
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