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1. WO2022029160 - METHOD FOR DETECTING AND QUANTIFYING ANALYTES IN A MICROFLUIDIC DEVICE

Publication Number WO/2022/029160
Publication Date 10.02.2022
International Application No. PCT/EP2021/071738
International Filing Date 04.08.2021
IPC
B01L 3/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
B01L 2300/0636
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0636Integrated biosensor, microarrays
B01L 2300/0645
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0645Electrodes
B01L 2300/0867
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0861Configuration of multiple channels and/or chambers in a single devices
0867Multiple inlets and one sample wells, e.g. mixing, dilution
B01L 3/5027
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
G01N 27/3272
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
327Biochemical electrodes ; , e.g. electrical or mechanical details for in vitro measurements
3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
3272Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
G01N 27/3278
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
327Biochemical electrodes ; , e.g. electrical or mechanical details for in vitro measurements
3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
3278involving nanosized elements, e.g. nanogaps or nanoparticles
Applicants
  • TECHNISCHE UNIVERSITÄT WIEN [AT]/[AT]
Inventors
  • ERTL, Peter
  • ALI, Syed, Faheem
  • SCHOBESBERGER, Silvia
  • SCHWEINBERGER, Selina
Agents
  • SCHWARZ & PARTNER PATENTANWÄLTE OG
  • PFÖSTL, Andreas
Priority Data
20189436.704.08.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR DETECTING AND QUANTIFYING ANALYTES IN A MICROFLUIDIC DEVICE
(FR) PROCÉDÉ DE DÉTECTION ET DE QUANTIFICATION D'ANALYTES DANS UN DISPOSITIF MICROFLUIDIQUE
Abstract
(EN) Microfluidic device (1) comprising at least one fluid channel (2) comprising at least one inlet (3), wherein said at least one fluid channel (2) is fluidly connected to a first sensor (4) downstream of said at least one fluid inlet (3), wherein the first sensor (4) comprises at least one sensor cathode (5) and at least one sensor anode (6) formed on an essentially electrically isolating substrate (7), wherein the sensor cathode (5) and the sensor anode (6) are spaced apart by a gap (8) formed on the electrically isolating substrate (7), and wherein at least one analyte capturing molecule (9) is immobilized in the gap (8) on the substrate (7), wherein the at least one capturing molecule (9) is adapted to capture at least one analyte (10) of a fluid sample introduced into the inlet (3) and transported to the first sensor (4).
(FR) La présente invention concerne un dispositif microfluidique (1) comprenant au moins un canal de fluide (2) comprenant au moins une entrée (3), ledit au moins un canal de fluide (2) étant en communication fluidique avec un premier capteur (4) en aval de ladite au moins une entrée de fluide (3), le premier capteur (4) comprenant au moins une cathode (5) de capteur et au moins une anode (6) de capteur formées sur un substrat essentiellement isolant électriquement (7), la cathode (5) de capteur et l'anode (6) de capteur étant espacées l'une de l'autre par un espace (8) formé sur le substrat électriquement isolant (7), et au moins une molécule (9) de capture d'analyte étant immobilisée dans l'espace (8) sur le substrat (7), ladite molécule de capture (9) étant conçue pour capturer au moins un analyte (10) d'un échantillon de fluide introduit dans l'entrée (3) et transporté vers le premier capteur (4).
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