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1. WO2022027066 - SURFACE ENHANCED RAMAN SPECTROSCOPY POINT OF CARE VIRUS DETECTION SYSTEM

Publication Number WO/2022/027066
Publication Date 03.02.2022
International Application No. PCT/US2021/071059
International Filing Date 29.07.2021
IPC
G01N 21/65 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
65Raman scattering
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
G01J 3/44 2006.1
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
44Raman spectrometry; Scattering spectrometry
CPC
G01J 2003/283
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
283computer-interfaced
G01J 2003/2833
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
28Investigating the spectrum
283computer-interfaced
2833and memorised spectra collection
G01J 3/0205
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
G01J 3/0208
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
0208using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
G01J 3/0229
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
0205Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
0229using masks, aperture plates, spatial light modulators or spatial filters, e.g. reflective filters
G01J 3/0275
GPHYSICS
01MEASURING; TESTING
JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRA-RED, VISIBLE OR ULTRA-VIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
3Spectrometry; Spectrophotometry; Monochromators; Measuring colours
02Details
0275making use of sensor-related data, e.g. for identification of sensor parts or optical elements
Applicants
  • TH BIOVENTURES, LLC [US]/[US]
  • HONDA, Leif, E. [US]/[US] (US)
  • CESTARO, Phil, A. [US]/[US] (US)
  • WETZEL, Jon, C. [US]/[US] (US)
  • LI, Songhao [US]/[US] (US)
  • HAJIAN, Arsen [US]/[US] (US)
  • SOSTEK, Ronald, J. [US]/[US] (US)
Inventors
  • HONDA, Leif, E.
  • CESTARO, Phil, A.
  • WETZEL, Jon, C.
  • LI, Songhao
  • HAJIAN, Arsen
  • SOSTEK, Ronald, J.
Agents
  • BURKHOLDER, Samuel, P.
  • SINGH, Jasbir
  • HEFLIN, Herman, R.
Priority Data
17/389,29229.07.2021US
63/058,18029.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SURFACE ENHANCED RAMAN SPECTROSCOPY POINT OF CARE VIRUS DETECTION SYSTEM
(FR) SYSTÈME DE DÉTECTION DE VIRUS DE POINT D’INTERVENTION À SPECTROSCOPIE RAMAN EXALTÉE DE SURFACE
Abstract
(EN) A system and method for detecting pathogenetic analytes including exciting a large target input area with radiation to produce scattered light to form an input beam, reformatting, with an optical sheer system, the input beam to produce an output beam, dispersing the output beam to produce an output area, capturing excitation data from the output area; and determining, with a processor, a presence of a particular analyte in the input area based on the excitation data. The input area can be greater than 100 micron squared and less than one million microns squared. The optical sheer system can be a high throughput virtual slit system. SERS analysis detects analytes of interest with both high resolution and sensitivity simultaneously, and is applicable for detection of the presence of viruses.
(FR) L'invention concerne un système et un procédé permettant de détecter des analytes pathogéniques comprenant l'excitation d'une grande zone d'entrée cible avec un rayonnement pour produire une lumière diffusée pour former un faisceau d'entrée, le reformatage, avec un système de cisaillement optique, le faisceau d'entrée afin de produire un faisceau de sortie, la dispersion du faisceau de sortie afin de produire une zone de sortie, la capture de données d'excitation à partir de la zone de sortie ; et la détermination, avec un processeur, d'une présence d'un analyte particulier dans la zone d'entrée sur la base des données d'excitation. La zone d'entrée peut être supérieure à 100 microns au carré et inférieure à un million de microns carrés. Le système de cisaillement optique peut être un système à fente virtuelle à haut débit. L'analyse de spectroscopie Raman exaltée de surface (SERS) détecte des analytes d'intérêt avec à la fois une résolution et une sensibilité élevées simultanément, et est applicable pour la détection de la présence de virus.
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