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1. WO2022023582 - METHODS FOR SCREENING COMPOUNDS FOR BACTERICIDAL ACTIVITY AND FOR DETERMINING THE SENSITIVITY OF BACTERIAL SAMPLES

Publication Number WO/2022/023582
Publication Date 03.02.2022
International Application No. PCT/EP2021/071592
International Filing Date 02.08.2021
IPC
C12Q 1/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
C12Q 1/18 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
02involving viable microorganisms
18Testing for antimicrobial activity of a material
C12Q 1/66 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
66involving luciferase
CPC
C12Q 1/008
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
008for determining co-enzymes or co-factors, e.g. NAD, ATP
C12Q 1/18
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
02involving viable microorganisms
18Testing for antimicrobial activity of a material
C12Q 1/66
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
66involving luciferase
Applicants
  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) [FR]/[FR]
  • UNIVERSITE PARIS-SACLAY [FR]/[FR]
Inventors
  • FOURMY, Dominique
  • YOSHIZAWA, Satoko
  • EBEYER-MASOTTA, Marie
  • PERNODET, Jean-Luc
Agents
  • REGIMBEAU
Priority Data
20305886.231.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR SCREENING COMPOUNDS FOR BACTERICIDAL ACTIVITY AND FOR DETERMINING THE SENSITIVITY OF BACTERIAL SAMPLES
(FR) PROCÉDÉS DE CRIBLAGE DE COMPOSÉS POUR UNE ACTIVITÉ BACTÉRICIDE ET POUR DÉTERMINER LA SENSIBILITÉ D'ÉCHANTILLONS BACTÉRIENS
Abstract
(EN) The present invention relates to a method for screening compounds for bactericidal activity using thermostable luciferase and based on a real-time bioluminescence measurement. The present invention further relates to a method for determining the sensitivity of a bacterial sample originating from a subject suffering from a bacterial infection to a group of known antibiotics and to a method for assessing the minimum inhibitory concentration (MIC) of a bactericidal compound.
(FR) La présente invention concerne un procédé de criblage de composés pour une activité bactéricide à l'aide de luciférase thermostable et basé sur une mesure de bioluminescence en temps réel. La présente invention concerne en outre un procédé de détermination de la sensibilité d'un échantillon bactérien provenant d'un sujet souffrant d'une infection bactérienne à un groupe d'antibiotiques connus et un procédé d'évaluation de la concentration minimale inhibitrice (CMI) d'un composé bactéricide.
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