WO2022022709 SIRPα-FC FUSION PROTEIN

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Publication Number WO/2022/022709

Publication Date 03.02.2022

International Application No. PCT/CN2021/109824

International Filing Date 30.07.2021

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Applicants

三生国健药业（上海）股份有限公司 SUNSHINE GUOJIAN PHARMACEUTICAL (SHANGHAI) CO., LTD. [CN]/[CN]

Inventors

赵杰 ZHAO, Jie
黄浩旻 HUANG, Haomin
朱祯平 ZHU, Zhenping

Agents

上海一平知识产权代理有限公司 XU&PARTNERS, LLC.

Priority Data

202010748225.0

30.07.2020

Publication Language Chinese (zh)

Filing Language Chinese (ZH)

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Title

(EN) SIRPα-FC FUSION PROTEIN

(FR) PROTÉINE DE FUSION SIRPα-FC

(ZH) 一种SIRPα-Fc融合蛋白

Abstract

(EN) Disclosed is a SIRPα-Fc fusion protein. The fusion protein comprises a SIRPαD1 domain variant and an immunoglobulin Fc region. The fusion protein of the present invention has the potential to treat diseases related to the SIRPα-CD47 signal pathway.

(FR) L'invention concerne une protéine de fusion SIRPα-Fc. La protéine de fusion comprend un variant de domaine SIRPαD1 et une région Fc d'immunoglobuline. La protéine de fusion de la présente invention a le potentiel de traiter des maladies associées à la voie de signalisation SIRPα-CD47.

(ZH) 本发明公开了SIRPα-Fc融合蛋白。所述融合蛋白包括SIRPαD1结构域变体和免疫球蛋白Fc区。本发明的融合蛋白具有治疗SIRPα-CD47信号通路相关疾病的潜力。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
46	from vertebrates
47	from mammals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
16	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17	from animals; from humans

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
46	from vertebrates
47	from mammals

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants

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1. WO2022022709 - SIRPα-FC FUSION PROTEIN

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
11	DNA or RNA fragments; Modified forms thereof
62	DNA sequences coding for fusion proteins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
68	the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
68	the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
2319	Fusion polypeptide
30	Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto