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1. WO2022015624 - SUBSTITUTED DIHYDROPYRAZINEDIONES AS MODULATORS OF THE NMDA RECEPTOR

Publication Number WO/2022/015624
Publication Date 20.01.2022
International Application No. PCT/US2021/041224
International Filing Date 12.07.2021
IPC
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07D 241/18 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Oxygen or sulfur atoms
C07D 401/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 403/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
10linked by a carbon chain containing aromatic rings
Applicants
  • SCHRÖDINGER, INC. [US]/[US]
Inventors
  • LEWIS, James
  • OSBORNE, James
  • TIERNEY, Jason
  • ELLARD, John
  • GORDON, James
  • PALOMERO-VAZQUEZ, Maria
  • JONES, Daniel
  • HIRST, Kim
  • SEPHTON, Mark
  • TARDIA, Piero
  • SHARPE, Andrew
  • TANG, Haifeng
  • BHAT, Sathesh
  • MCROBB, Fiona
  • HOUANG, Evelyne
  • DAHLGREN, Markus
Agents
  • BATES, Caleb A.
  • SPENCER, William T.
Priority Data
63/052,74916.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED DIHYDROPYRAZINEDIONES AS MODULATORS OF THE NMDA RECEPTOR
(FR) DIHYDROPYRAZINEDIONES SUBSTITUÉES EN TANT QUE MODULATEURS DU RÉCEPTEUR NMDA
Abstract
(EN) This present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I) and pharmaceutically acceptable salts thereof and methods of using the compounds and compositions for treating neurological disorders such as schizophrenia, mild cognitive impairment and chronic neuropathic pain.
(FR) La présente invention concerne des composés de Formule (I), tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. La présente invention concerne également une composition pharmaceutique comprenant un composé de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des procédés d'utilisation des composés et des compositions pour traiter des troubles neurologiques tels que la schizophrénie, un trouble cognitif léger et une douleur neuropathique chronique.
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