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1. WO2022011391 - SALTS AND FORMS OF A WEE1 INHIBITOR

Publication Number WO/2022/011391
Publication Date 13.01.2022
International Application No. PCT/US2021/070851
International Filing Date 08.07.2021
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07B 2200/13
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
13Crystalline forms, e.g. polymorphs
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • RECURIUM IP HOLDINGS, LLC [US]/[US]
Inventors
  • HOPKINS, Chad, Daniel
  • HUANG, Peter, Qinhua
  • BUNKER, Kevin, Duane
Agents
  • MILLER, Kimberly, J.
Priority Data
63/049,99609.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SALTS AND FORMS OF A WEE1 INHIBITOR
(FR) SELS ET FORMES D'UN INHIBITEUR DE WEE1
Abstract
(EN) The salt, such as adipate salt Form A, and freebase forms of Compound A are WEE1 inhibitors. Such salts and/or forms and freebase forms, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as breast cancer.
(FR) Le sel, tel qu'une forme A de sel d'adipate, et des formes à base libre du composé A sont des inhibiteurs de WEE1. Ces sels et/ou formes et formes de base libre, ainsi que des sels pharmaceutiquement acceptables et des compositions de ceux-ci, sont utiles pour le traitement de maladies ou d'affections, notamment d'affections caractérisées par une prolifération cellulaire excessive, telles que le cancer du sein.
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