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1. WO2022011338 - KINASE MODULATORS AND METHODS OF USE THEREOF

Publication Number WO/2022/011338
Publication Date 13.01.2022
International Application No. PCT/US2021/041271
International Filing Date 12.07.2021
IPC
C07D 249/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
Applicants
  • ORIGENIS GMBH [DE]/[DE]
  • NEURON23, INC. [US]/[US]
Inventors
  • KOESTLER, Roland
  • YEHIA, Nasser
  • TASSEL, Jean
  • WEGMANN, Marcus
  • MEDDA, Federico
  • PEREZ-GALAN, Patricia
  • GILCH, Christiane
  • THORMANN, Michael
  • TREML, Andreas
  • ALMSTETTER, Michael
  • PEI, Zhonghua
  • SAVAGE, Scott
Agents
  • SCHOEN, Adam M.
  • HYDE, Zachary, D.
  • DIBERNARDO, Ian, G.
  • MEYERS, Thomas, C.
  • NICKAS, Mark
Priority Data
63/050,38510.07.2020US
63/137,81615.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) KINASE MODULATORS AND METHODS OF USE THEREOF
(FR) MODULATEURS DE KINASE ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN) The present invention relates to novel compounds that modulate the activity of one or more kinases, such as TYK2 or mutants thereof. The compounds, which may be kinase inhibitors or activators, are useful for treating autoimmune diseases, such as, such as psoriasis, lupus, multiple sclerosis, and inflammatory bowel disease.
(FR) La présente invention concerne de nouveaux composés qui modulent l'activité d'une ou de plusieurs kinases, par exemple TYK2 ou des mutants associés. Les composés, qui peuvent être des inhibiteurs ou des activateurs de kinase, sont utiles pour le traitement de maladies auto-immunes, telles que le psoriasis, le lupus, la sclérose en plaques et la maladie intestinale inflammatoire.
Latest bibliographic data on file with the International Bureau