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1. WO2022011337 - KINASE MODULATORS AND METHODS OF USE THEREOF

Publication Number WO/2022/011337
Publication Date 13.01.2022
International Application No. PCT/US2021/041270
International Filing Date 12.07.2021
IPC
A61K 31/506 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
A61K 31/517 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
Applicants
  • ORIGENIS GMBH [DE]/[DE]
  • NEURON23, INC. [US]/[US]
Inventors
  • KOESTLER, Roland
  • YEHIA, Nasser
  • TASSEL, Jean
  • WEGMANN, Marcus
  • MEDDA, Federico
  • PEREZ-GALLAN, Patricia
  • GILCH, Christiane
  • THORMANN, Michael
  • TREML, Andreas
  • ALMSTETTER, Michael
  • PEI, Zhonghua
  • SAVAGE, Scott
Agents
  • SCHOEN, Adam, M.
  • HYDE, Zachary, D.
  • NICKAS, Mark
  • DIBERNARDO, Lan, G.
  • MEYERS, Thomas, C.
Priority Data
63/050,38210.07.2020US
63/137,81415.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) KINASE MODULATORS AND METHODS OF USE THEREOF
(FR) MODULATEURS DE KINASE ET LEURS PROCÉDÉS D'UTILISATION
Abstract
(EN) The present invention relates to novel compounds that modulate the activity of one or more kinases, such as TYK2 or mutants thereof. The compounds, which may be kinase inhibitors or activators, are useful for treating autoimmune diseases, such as, such as psoriasis, lupus, multiple sclerosis, and inflammatory bowel disease.
(FR) La présente invention concerne de nouveaux composés qui modulent l'activité d'une ou de plusieurs kinases, par exemple TYK2 ou des mutants associés. Les composés, qui peuvent être des inhibiteurs ou des activateurs de kinase, sont utiles pour le traitement de maladies auto-immunes, telles que le psoriasis, le lupus, la sclérose en plaques et la maladie intestinale inflammatoire.
Latest bibliographic data on file with the International Bureau