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1. WO2022011222 - COMPOSITIONS AND METHODS FOR TREATING CANCER-ASSOCIATED CACHEXIA

Publication Number WO/2022/011222
Publication Date 13.01.2022
International Application No. PCT/US2021/041029
International Filing Date 09.07.2021
IPC
A61N 1/36 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation, e.g. heart pace-makers
A61N 1/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
02Details
04Electrodes
05for implantation or insertion into the body, e.g. heart electrode
A61H 99/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
99Subject matter not provided for in other groups of this subclass
CPC
A61H 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
HPHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
1Apparatus for passive exercising
A61N 1/0556
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
02Details
04Electrodes
05for implantation or insertion into the body, e.g. heart electrode
0551Spinal or peripheral nerve electrodes
0556Cuff electrodes
A61N 1/36002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation
36002Cancer treatment, e.g. tumour
A61N 1/36053
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
1Electrotherapy; Circuits therefor
18Applying electric currents by contact electrodes
32alternating or intermittent currents
36for stimulation
3605Implantable neurostimulators for stimulating central or peripheral nerve system
36053adapted for vagal stimulation
Applicants
  • DUKE UNIVERSITY [US]/[US]
Inventors
  • SHEN, Xiling
  • O'RAW, Aliesha
  • MORIZIO, James
  • DESHMUKH, Ashlesha
Agents
  • ELLIOTT, Allyn B.
Priority Data
63/050,35210.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR TREATING CANCER-ASSOCIATED CACHEXIA
(FR) COMPOSITIONS ET PROCÉDÉ PERMETTANT DE TRAITER LA CACHEXIE ASSOCIÉE À UN CANCER
Abstract
(EN) A method for treating cachexia in a subject in need thereof includes stimulating the parasympathetic nervous system of the subject thereby treating cachexia in the subject. Stimulating the parasympathetic nervous system can increase expression of urea cycle enzymes in the liver of the subject. Parasympathetic nervous system stimulation can comprise stimulating the vagus nerve, for example, the cervical vagus nerve or the hepatic branch of the vagus nerve. Pulses can be delivered at a frequency ranging from 1 Hz to 10Hz or at a frequency of about 5 kHz.
(FR) L'invention concerne un procédé de traitement de la cachexie chez un sujet qui en a besoin, le procédé comprenant la stimulation du système nerveux parasympathique du sujet, ce qui permet de traiter la cachexie chez le sujet. La stimulation du système nerveux parasympathique peut augmenter l'expression d'enzymes de cycle de l'urée dans le foie du sujet. La stimulation du système nerveux parasympathique peut comprendre la stimulation du nerf vague, par exemple, le nerf vague cervical ou la branche hépatique du nerf vague. Des impulsions peuvent être délivrées à une fréquence allant de 1 Hz à 10 Hz ou à une fréquence d'environ 5 kHz.
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