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1. WO2022011211 - DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS

Publication Number WO/2022/011211
Publication Date 13.01.2022
International Application No. PCT/US2021/041007
International Filing Date 09.07.2021
Chapter 2 Demand Filed 10.05.2022
IPC
A61K 31/445 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07D 211/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
36with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
40Oxygen atoms
44attached in position 4
46having a hydrogen atom as the second substituent in position 4
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
Applicants
  • EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. [US]/[US]
Inventors
  • HILL, Daniel Cope
  • KENNEDY, Isaac, A.
  • LAM, Patrick, Y., S.
  • TRESTON, Anthony, M.
  • WARFIELD, Kelly, Lyn
Agents
  • BODENSTEIN, Matthew, S.
  • BANOWIT, Donald R.
  • BEMBEN, Richard M.
  • BEZOS, Salvador M.
  • BLOCK, Daniel S.
  • CALVO, Paul A.
  • CAMARCE, Christian A.
  • CIMBALA, Michele A.
  • COLLER III, Richard D.
  • CONKLIN, Kyle E.
  • COVERT, John M.
  • DESAI, Nirav N.
  • DURKIN, Tracy-Gene G.
  • EISENBERG, Jason D.
  • ELLISON, Eldora L.
  • ESMOND, Robert W.
  • FEATHERSTONE, Donald J.
  • FITZSIMMONS, Jason A.
  • FRUEAUF, Jeremiah B.
  • GAJEWSKI, Daniel A.
  • GLENN, Dallin G.
  • GOLDSTEIN, Jorge A.
  • HELVEY, Jeffrey T.
  • HICKS, Ross G.
  • HOLMAN, David H.
  • HOLOUBEK, Michelle K.
  • JACKMAN, Peter A.
  • KENTON, JR., Lestin L.
  • KIM, Ji Eun
  • LAROCK, Adam C.
  • LEE, Michael Q.
  • LONGSWORTH, Gaby L.
  • MILLONIG, Robert C.
  • MUTSCHELKNAUS, Joseph
  • NANNENGA-COMBS, Bonnie W.
  • PHERO, Graham C.
  • PICKARD, Byron L.
  • RAY, Michael B.
  • RICHARDSON, Ryan C.
  • ROSE GILLENTINE, Marsha
  • RYGIEL, Mark W.
  • SHEA, JR., Timothy J.
  • SOKOHL, Robert E.
  • STEFFE, Eric K.
  • STERLING, Deborah A.
  • STERNE, Robert Greene
  • TUMINARO, Jonathan
  • SPECHT, Michael D.
  • VIRA, Chandrika
  • VARUGHESE, Dennies
  • POWERS III, R. Wilson
  • WRIGHT, Jon E.
  • YONAN, Daniel E.
  • KIM, Josephine
Priority Data
62/705,69810.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS
(FR) DÉRIVÉS DE DÉSOXYNOJIRIMYCINE EN TANT QU'INHIBITEURS DE GLUCOSIDASE
Abstract
(EN) The present application provides novel iminosugars and their use as glucosidase inhibitors. The present inventors have discovered that certain deoxynojirimycin derivatives may be effective in inhibiting glucosidases. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition where inhibiting glucosidase may be important.
(FR) La présente invention concerne de nouveaux iminosucres et leur utilisation en tant qu'inhibiteurs de glucosidase. Les présents inventeurs ont découvert que certains dérivés de désoxynojirimycine peuvent être efficaces pour inhiber les glucosidases. En particulier, de tels dérivés de désoxynojirimycine peuvent être utiles pour traiter une maladie ou un état dans lequel l'inhibition d'une glucosidase peut jouer un rôle important.
Latest bibliographic data on file with the International Bureau