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1. WO2022011211 - DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS

Publication Number WO/2022/011211
Publication Date 13.01.2022
International Application No. PCT/US2021/041007
International Filing Date 09.07.2021
IPC
A61K 31/445 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
Applicants
  • EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC. [US]/[US]
Inventors
  • HILL, Daniel Cope
  • KENNEDY, Isaac, A.
  • LAM, Patrick, Y., S.
  • TRESTON, Anthony, M.
  • WARFIELD, Kelly, Lyn
Agents
  • BODENSTEIN, Matthew, S.
  • BANOWIT, Donald R.
  • BEMBEN, Richard M.
  • BEZOS, Salvador M.
  • BLOCK, Daniel S.
  • CALVO, Paul A.
  • CAMARCE, Christian A.
  • CIMBALA, Michele A.
  • COLLER III, Richard D.
  • CONKLIN, Kyle E.
  • COVERT, John M.
  • DESAI, Nirav N.
  • DURKIN, Tracy-Gene G.
  • EISENBERG, Jason D.
  • ELLISON, Eldora L.
  • ESMOND, Robert W.
  • FEATHERSTONE, Donald J.
  • FITZSIMMONS, Jason A.
  • FRUEAUF, Jeremiah B.
  • GAJEWSKI, Daniel A.
  • GLENN, Dallin G.
  • GOLDSTEIN, Jorge A.
  • HELVEY, Jeffrey T.
  • HICKS, Ross G.
  • HOLMAN, David H.
  • HOLOUBEK, Michelle K.
  • JACKMAN, Peter A.
  • KENTON, JR., Lestin L.
  • KIM, Ji Eun
  • LAROCK, Adam C.
  • LEE, Michael Q.
  • LONGSWORTH, Gaby L.
  • MILLONIG, Robert C.
  • MUTSCHELKNAUS, Joseph
  • NANNENGA-COMBS, Bonnie W.
  • PHERO, Graham C.
  • PICKARD, Byron L.
  • RAY, Michael B.
  • RICHARDSON, Ryan C.
  • ROSE GILLENTINE, Marsha
  • RYGIEL, Mark W.
  • SHEA, JR., Timothy J.
  • SOKOHL, Robert E.
  • STEFFE, Eric K.
  • STERLING, Deborah A.
  • STERNE, Robert Greene
  • TUMINARO, Jonathan
  • SPECHT, Michael D.
  • VIRA, Chandrika
  • VARUGHESE, Dennies
  • POWERS III, R. Wilson
  • WRIGHT, Jon E.
  • YONAN, Daniel E.
  • KIM, Josephine
Priority Data
62/705,69810.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS
(FR) DÉRIVÉS DE DÉSOXYNOJIRIMYCINE EN TANT QU'INHIBITEURS DE GLUCOSIDASE
Abstract
(EN) The present application provides novel iminosugars and their use as glucosidase inhibitors. The present inventors have discovered that certain deoxynojirimycin derivatives may be effective in inhibiting glucosidases. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition where inhibiting glucosidase may be important.
(FR) La présente invention concerne de nouveaux iminosucres et leur utilisation en tant qu'inhibiteurs de glucosidase. Les présents inventeurs ont découvert que certains dérivés de désoxynojirimycine peuvent être efficaces pour inhiber les glucosidases. En particulier, de tels dérivés de désoxynojirimycine peuvent être utiles pour traiter une maladie ou un état dans lequel l'inhibition d'une glucosidase peut jouer un rôle important.
Latest bibliographic data on file with the International Bureau