Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022011204 - SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS

Publication Number WO/2022/011204
Publication Date 13.01.2022
International Application No. PCT/US2021/040988
International Filing Date 09.07.2021
IPC
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 451/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
02containing not further condensed 8-azabicyclo octane or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane; Cyclic acetals thereof
04with hetero atoms directly attached in position 3 of the 8-azabicyclo octane or in position 7 of the 3-oxa-9-azatricyclo nonane ring system
06Oxygen atoms
C07D 451/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
451Heterocyclic compounds containing 8-azabicyclo octane, 9-azabicyclo nonane, or 3-oxa-9-azatricyclo nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
14containing 9-azabicyclo nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
08Bridged systems
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US]
Inventors
  • WANG, Shaomeng
  • HAN, Xin
  • XIANG, Weiguo
  • QIN, Chong
  • XU, Tianfeng
  • ZHAO, Lijie
Agents
  • NAPOLI, James, J.
Priority Data
63/050,23310.07.2020US
63/166,05925.03.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SMALL MOLECULE ANDROGEN RECEPTOR PROTEIN DEGRADERS
(FR) AGENTS DE DÉGRADATION DES PROTÉINES DU RÉCEPTEUR DES ANDROGÈNES À PETITES MOLÉCULES
Abstract
(EN) The present disclosure provides compounds represented by Formula I: A-L-B1 I, and the salts or solvates thereof, wherein A, L, and B1 are as defined in the specification. Compounds having Formula I are androgen receptor degraders useful for the treatment of cancer and other diseases.
(FR) La présente invention concerne des composés représentés par la formule I : A-L-B1 I, et leurs sels ou solvates, A, L et B1 étant tels que définis dans le descriptif. Les Composés De formule I sont des agents de dégradation du récepteur des androgènes utiles pour le traitement du cancer et d'autres maladies.
Latest bibliographic data on file with the International Bureau