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1. WO2022011083 - PYRAZOLONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS

Publication Number WO/2022/011083
Publication Date 13.01.2022
International Application No. PCT/US2021/040793
International Filing Date 08.07.2021
IPC
C07D 231/44 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
44Oxygen and nitrogen or sulfur and nitrogen atoms
C07D 401/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 401/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
C07D 407/14 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
407Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/183
14containing three or more hetero rings
C07D 413/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US]
Inventors
  • JOHNSON, James A.
  • PI, Zulan
  • WURTZ, Nicholas R.
  • SMALLHEER, Joanne M.
  • VALENTE, Meriah Neissel
  • KICK, Ellen K.
  • CLARK, Charles G.
  • SHIRUDE, Pravin Sudhakar
  • SESHADRI, Balaji
  • CHATTOPADHYAY, Amit Kumar
Agents
  • LIU, Hong
  • BARBIC, Andre
  • BELLOMY, Gregory R.
  • CLAUSS, Isabelle M.
  • COULTER, Kathryn
  • DELAUNEY, Ashton J.
  • FARQUHARSON-TORRES, Serena
  • GOLIAN, Paul D.
  • GREENBLATT, Gary D.
  • GUO, Z. Angela
  • HADAD, Henry
  • HAI, Bing
  • HAN, Bo
  • HICKEY, Denise
  • JACOBSEN, Barry H.
  • KORSEN, Elliott
  • LAUB, Friedrich Bernhard
  • LIU, Xiangyu
  • SUN, Jing G.
  • VANATTEN, Mary K.
  • VOM WEGE, Julia
  • WALSH, Brian J.
  • WENK, Melissa
Priority Data
63/049,83109.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PYRAZOLONE FORMYL PEPTIDE 2 RECEPTOR AGONISTS
(FR) AGONISTES DU RÉCEPTEUR 2 DU PEPTIDE FORMYLÉ DE PYRAZOLONE
Abstract
(EN) The disclosure relates to compounds of formula I, which are formyl peptide 2 (FPR2) receptor agonists. The disclosure also provides compositions and methods of using the compounds, for example, for the treatment of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.
(FR) L'invention concerne des composés de formule (I) qui sont des agonistes du récepteur 2 du peptide formylé (FPR2). L'invention concerne également des compositions et des procédés d'utilisation des composés, par exemple, pour le traitement de l'athérosclérose, de l'insuffisance cardiaque, de la bronchopneumopathie chronique obstructive (BPCO) et de maladies associées.
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