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1. WO2022011032 - METHOD OF PRODUCING MODIFIED VIRUS GENOMES AND PRODUCING MODIFIED VIRUSES

Publication Number WO/2022/011032
Publication Date 13.01.2022
International Application No. PCT/US2021/040716
International Filing Date 07.07.2021
IPC
C12N 7/00 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
C12N 7/02 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
02Recovery or purification
C12N 15/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
C12Q 1/6844 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6844Nucleic acid amplification reactions
Applicants
  • CODAGENIX INC. [US]/[US]
Inventors
  • COLEMAN, John Robert
  • MUELLER, Steffen
  • YANG, Chen
  • WANG, Ying
  • SONG, Yutong
Agents
  • HUBER, Linda B.
  • LEVY, Seth D.
  • HAYES, Jennifer
  • KESAVAN, Sowmya
  • ZHU, Samantha (Suwei)
Priority Data
63/048,94707.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF PRODUCING MODIFIED VIRUS GENOMES AND PRODUCING MODIFIED VIRUSES
(FR) PROCÉDÉ DE PRODUCTION DE GÉNOMES DE VIRUS MODIFIÉS ET PRODUCTION DE VIRUS MODIFIÉS
Abstract
(EN) The present invention describes methods of generating a modified viral genome, producing infectious RNA, and generating modified viruses. The modified viral genome, infections RNA, and modified viruses comprise deoptimized nucleic acids; for example, codon-pair deoptimized or synonymous codon deoptimized. These modified viruses can be used in vaccines and methods of eliciting a protective immune response.
(FR) La présente invention décrit des procédés de génération d'un génome viral modifié, de production d'ARN infectieux et de génération de virus modifiés. Le génome viral modifié, l'ARN infectieux et les virus modifiés comprennent des acides nucléiques désoptimisés ; par exemple, désoptimisés pour une paire de codons ou désoptimisés pour un codon synonyme. Ces virus modifiés peuvent être utilisés dans des vaccins et des procédés de déclenchement d'une réponse immunitaire protectrice.
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