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1. WO2022011010 - TRANSGENIC MOUSE MODEL EXPRESSING HUMAN HLA-A201 RESTRICTION GENE

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Publication Number WO/2022/011010
Publication Date 13.01.2022
International Application No. PCT/US2021/040682
International Filing Date 07.07.2021
IPC
A01K 67/02 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
02Breeding vertebrates
A01K 67/027 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
C07K 14/705 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 14/74 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
74Major histocompatibility complex (MHC)
Applicants
  • THE JACKSON LABORATORY [US]/[US]
Inventors
  • PALUCKA, Anna, Karolina
  • YU, Chun, I.
  • BANCHEREAU, Jacques
  • MASER, Richard
  • SHULTZ, Leonard, D.
Agents
  • MULSKI, Elizabeth, S.
  • BAKER, C., Hunter
  • ATTISHA, Michael, J.
  • AMUNDSEN, Eric, L.
  • ALAM, Saad
Priority Data
63/049,18708.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRANSGENIC MOUSE MODEL EXPRESSING HUMAN HLA-A201 RESTRICTION GENE
(FR) MODÈLE DE SOURIS TRANSGÉNIQUE EXPRIMANT UN GÈNE DE RESTRICTION HLA-A201 HUMAIN
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Abstract
(EN) The present disclosure provides an immunodeficient NOD.Cg -Prkdcscid Il2rgtm1Wjl/SzJ (NSG™) mouse models that comprise an inactivated mouse Flt3 allele, a nucleic acid encoding human interleukin 3 (IL3), a nucleic acid encoding human granulocyte/macrophage-stimulating factor (GM-CSF), a nucleic acid encoding human stem cell factor (SCF), and a HLA-A2/H2- D/B2M transgene encoding (i) a human B2-microglubulin (B2M) covalently linked to MHC class 1, alpha 1, and alpha2 binding domains of a human HLA-A2.1 gene and (ii) alpha3 cytoplasmic and transmembrane domains of murine H2-Db.
(FR) La présente divulgation concerne des modèles de souris NOD.Cg-Prkdc scid Il2rg tm1Wjl/SzJ (NSG™) immunodéficientes qui comprennent un allèle Flt3 murin inactivé, un acide nucléique codant pour l'interleukine 3 (IL3) humaine, un acide nucléique codant pour le facteur de stimulation des granulocytes/macrophages (GM-CSF) humains, un acide nucléique codant pour le facteur de cellule souche (SCF) humaine, et un transgène HLA-A2/H2-D/B2M codant pour (i) une B2 microglubuline (B2M) humaine liée de manière covalente à des domaines de liaison au CMH de classe 1, alpha 1 et alpha 2 d'un gène HLA-A2.1 humain et (ii) des domaines cytoplasmiques et transmembranaires alpha 3 de H2-Db murin.
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