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1. WO2022011001 - METHOD FOR ANTIGEN DETECTION FROM DIRECT CLINICAL SAMPLES

Publication Number WO/2022/011001
Publication Date 13.01.2022
International Application No. PCT/US2021/040672
International Filing Date 07.07.2021
IPC
A61K 39/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
04Mycobacterium, e.g. Mycobacterium tuberculosis
A61K 39/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/42 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
A61K 39/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
G01N 27/403 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
403Cells and electrode assemblies
G01N 33/553 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
551the carrier being inorganic
553Metal or metal coated
CPC
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 16/1289
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
12against material from bacteria
1267from Gram-positive bacteria
1289from Mycobacteriaceae (F)
G01N 2333/165
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
G01N 2333/35
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
195from bacteria
35from Mycobacteriaceae (F)
G01N 27/327
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
28Electrolytic cell components
30Electrodes, e.g. test electrodes; Half-cells
327Biochemical electrodes ; , e.g. electrical or mechanical details for in vitro measurements
G01N 33/553
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
551the carrier being inorganic
553Metal or metal coated
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • RODWELL, Timothy
  • CATANZARO, Antonino
  • SEIFERT, Marva
  • WANG, Joseph
  • ORGAZ, Eva Vargas
  • MONTIEL, Victor Ruiz Valdepenas
Agents
  • FANG, Lei
Priority Data
63/048,98907.07.2020US
63/067,96320.08.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR ANTIGEN DETECTION FROM DIRECT CLINICAL SAMPLES
(FR) PROCÉDÉ DE DÉTECTION D'ANTIGÈNES À PARTIR D'ÉCHANTILLONS CLINIQUES DIRECTS
Abstract
(EN) In one aspect, the disclosure relates to test strips for detecting and/or monitoring the treatment of a disease in a subject. The test strips are inexpensive and disposable and can be used directly with clinical biological samples from patients including, but not limited to, blood, plasma, saliva, and urine. Also disclosed are methods of using the test strips to quantify antigens produced by a virus or microorganism causing an infectious disease. The methods can be conducted at a point of care for a patient and do not require expensive equipment or extensive operator training. The methods are also rapid to complete and can be used to monitor progress in the treatment of a disease This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
(FR) Selon un aspect, la divulgation porte sur des bandelettes réactives permettant de détecter et/ou de surveiller le traitement d'une maladie chez un sujet. Les bandelettes réactives sont peu coûteuses et jetables et peuvent être directement utilisées avec des échantillons biologiques cliniques de patients, comprenant non exclusivement du sang, du plasma, de la salive et de l'urine. Sont également divulgués des procédés d'utilisation des bandelettes réactives pour quantifier des antigènes produits par un virus ou un micro-organisme provoquant une maladie infectieuse. Les procédés peuvent être mis en œuvre au niveau d'un point d'intervention pour un patient et ne nécessitent pas d'équipement coûteux ni d'entraînement approfondi de l'opérateur. Les procédés sont également rapides à achever et peuvent être utilisés pour surveiller le progrès du traitement d'une maladie. Cet abrégé est destiné à servir d'outil d'exploration à des fins de recherche dans l'état particulier de la technique et n'est pas destiné à limiter la présente divulgation.
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