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1. WO2022010948 - NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF FOR THE TREATMENT OF VIRAL DISEASES

Publication Number WO/2022/010948
Publication Date 13.01.2022
International Application No. PCT/US2021/040584
International Filing Date 06.07.2021
IPC
A61K 31/122 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
12Ketones
122having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A61K 31/15 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
15Oximes ; Hydrazines ; Hydrazones
A61K 31/194 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
194having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
Applicants
  • CRESCENTA BIOSCIENCES [US]/[US]
Inventors
  • KOYUNCU, Emre
  • KIM, Hahn
  • HOTAMISLIGIL, Gokhan
Agents
  • GEARHART, Richard
Priority Data
63/048,61906.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF FOR THE TREATMENT OF VIRAL DISEASES
(FR) NOUVEAUX COMPOSÉS MODULANT LE MÉTABOLISME CELLULAIRE ET LEURS UTILISATIONS POUR LE TRAITEMENT DE MALADIES VIRALES
Abstract
(EN) A class of compounds that bind to FABP4 and inhibit viral replication in cells, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with an additional therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of viral diseases. Formula I
(FR) L'invention concerne une classe de composés qui se lient à FABP4 et inhibent la réplication virale dans les cellules, ainsi que des compositions pharmaceutiques comprenant ladite classe de composés, en association avec un diluant ou un support pharmaceutiquement acceptable, et éventuellement, également en association avec un agent thérapeutiquement actif additionnel, ainsi que l'utilisation de ces composés en médecine et pour la préparation d'un médicament destiné au traitement de maladies virales. Formule I
Latest bibliographic data on file with the International Bureau