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1. WO2022010925 - METHODS OF TREATING DISEASES AND DISORDERS WITH DEUPIRFENIDONE

Publication Number WO/2022/010925
Publication Date 13.01.2022
International Application No. PCT/US2021/040551
International Filing Date 06.07.2021
IPC
A61K 31/4418 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4418having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
Applicants
  • PURETECH LYT 100, INC. [US]/[US]
Inventors
  • ELENKO, Eric
  • CHEN, Michael C.
Agents
  • HERRITT, Danielle L.
  • BREINING, Scott R.
Priority Data
63/048,56406.07.2020US
63/087,11602.10.2020US
63/116,52020.11.2020US
63/121,16803.12.2020US
63/123,98910.12.2020US
63/135,37408.01.2021US
63/175,06315.04.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF TREATING DISEASES AND DISORDERS WITH DEUPIRFENIDONE
(FR) PROCÉDÉS DE TRAITEMENT DES MALADIES ET DES TROUBLES PAR LA DEUPIRFÉNIDONE
Abstract
(EN) Disclosed herein are methods of treating a fibrotic-mediated disorder or a collagen-mediated disorder, that include administering to a subject in need thereof a high dose of deupirfenidone, e.g., a total daily dose of up to 2500 mg. Also disclosed are interventional dosing for functionally impairing diseases and dosing for chronic disease.
(FR) L'invention concerne des méthodes de traitement d'un trouble à médiation fibrogène ou d'un trouble à médiation collagène, qui comprennent l'administration à un sujet qui en a besoin d'une dose élevée de deupirfénidone, par exemple une dose quotidienne totale allant jusqu'à 2500 mg. L'invention concerne également le dosage interventionnel pour les maladies altérant les fonctions et le dosage pour les maladies chroniques.
Latest bibliographic data on file with the International Bureau