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1. WO2022010914 - BRK PEPTIDES AND METHODS OF USE

Publication Number WO/2022/010914
Publication Date 13.01.2022
International Application No. PCT/US2021/040536
International Filing Date 06.07.2021
IPC
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • CONCARLO HOLDINGS, LLC [US]/[US]
Inventors
  • BRIDON, Dominique
Agents
  • HAILE, Lisa A.
  • HIERHOLZER, Matthew J.
  • HWANG, Pamela E.
Priority Data
63/048,48906.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) BRK PEPTIDES AND METHODS OF USE
(FR) PEPTIDES BRK ET PROCÉDÉS D'UTILISATION
Abstract
(EN) The invention relates to truncated isolated BRK peptides and functional peptides thereof that inhibit the phosphorylation of p27Kip1 and the resulting kinase activity of CDK2 and CDK4; and to pharmaceutical compositions thereof. The invention further relates to the use of the isolated peptides in methods of treating cancer in subject in need thereof.
(FR) L'invention concerne des peptides BRK isolés tronqués et des peptides fonctionnels de ceux-ci qui inhibent la phosphorylation de p27Kip1 et l'activité kinase résultante de CDK2 et CDK4 ; et leurs compositions pharmaceutiques. L'invention concerne en outre l'utilisation des peptides isolés dans des méthodes de traitement du cancer chez un sujet ayant besoin d'un tel traitement.
Latest bibliographic data on file with the International Bureau