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1. WO2022010891 - FETAL TROPHOBLAST COMPOSITIONS AND METHODS

Publication Number WO/2022/010891
Publication Date 13.01.2022
International Application No. PCT/US2021/040503
International Filing Date 06.07.2021
IPC
C12Q 1/6886 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 1/6879 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6879for sex determination
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
A61B 10/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
10Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
02Instruments for taking cell samples or for biopsy
Applicants
  • NEXTGEN JANE, INC. [US]/[US]
Inventors
  • GIRE, Stephen
  • TARIYAL, Ridhi
  • MIR, Alain
Agents
  • FLOYD, Jennifer A.
Priority Data
63/048,84507.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) FETAL TROPHOBLAST COMPOSITIONS AND METHODS
(FR) COMPOSITIONS DE TROPHOBLASTES FŒTAUX ET MÉTHODES
Abstract
(EN) Provided herein are compositions comprising populations of cells obtained from a pregnant subject comprising at least one of a Hofbauer cell, a cytotrophoblast, a syncytiotrophoblast, an extravillous trophoblast, a villous core stroma, or a fetal vascular cell; a stabilization buffer, wherein the stabilization buffer comprises a preservative; and a cellulosic collection device, wherein at least a subset of the population of cells are intact and inviable and methods of making and using such compositions.
(FR) L'invention concerne des compositions comprenant des populations de cellules obtenues à partir d'une femme enceinte comprenant une cellule de Hofbauer, un cytotrophoblaste, un syncytiotrophoblaste, un trophoblaste extra-villositaire, un stroma de cœur villositaire et/ou une cellule vasculaire fœtale; un tampon de stabilisation, le tampon de stabilisation comprenant un conservateur; et un dispositif de collecte cellulosique, au moins un sous-ensemble de la population de cellules étant intact et inviable et des méthodes de fabrication et d'utilisation de telles compositions.
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