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1. WO2022010880 - KCNT1 INHIBITORS AND METHODS OF USE

Publication Number WO/2022/010880
Publication Date 13.01.2022
International Application No. PCT/US2021/040486
International Filing Date 06.07.2021
IPC
A61K 31/015 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
01Hydrocarbons
015carbocyclic
A61K 31/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
A61K 31/4192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41921,2,3-Triazoles
Applicants
  • PRAXIS PRECISION MEDICINES, INC. [US]/[US]
Inventors
  • GRIFFIN, Andrew Mark
  • MARTINEZ BOTELLA, Gabriel
Agents
  • CHOI, Anita
Priority Data
63/048,33506.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) KCNT1 INHIBITORS AND METHODS OF USE
(FR) INHIBITEURS DE KCNT1 ET PROCÉDÉS D'UTILISATION
Abstract
(EN) The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.
(FR) La présente invention concerne, en partie, des composés et des compositions utiles pour prévenir et/ou traiter une maladie ou un trouble neurologique, une maladie ou un état se rapportant à une excitabilité neuronale excessive, et/ou une mutation de gain de fonction dans un gène (par ex., KCNT1). L'invention concerne également des procédés de traitement d'une maladie ou d'un trouble neurologique, d'une maladie ou d'un état se rapportant à une excitabilité neuronale excessive et/ou à une mutation de gain de fonction dans un gène tel que KCNT1.
Latest bibliographic data on file with the International Bureau