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1. WO2022010860 - INFECTIOUS RECOMBINANT VESICULAR STOMATITIS VIRUS (RVSV) BEARING THE SPIKE GLYCOPROTEIN S OF SARS-COV-2 AND USES THEREOF

Publication Number WO/2022/010860
Publication Date 13.01.2022
International Application No. PCT/US2021/040460
International Filing Date 06.07.2021
IPC
A61K 39/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
215Coronaviridae, e.g. avian infectious bronchitis virus
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C12N 15/86 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
A61K 38/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Applicants
  • ALBERT EINSTEIN COLLEGE OF MEDICINE [US]/[US]
  • CHANDRAN, Kartik [IN]/[US]
  • JANGRA, Rohit, K. [IN]/[US]
Inventors
  • CHANDRAN, Kartik
  • JANGRA, Rohit, K.
Agents
  • HUESTIS, Erik, A.
  • ABELLEIRA, Susan, M.
  • AKHIEZER, Alexander
  • CAI, Mi
  • CHATTERLEY, Alexander, J.
Priority Data
63/048,91807.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INFECTIOUS RECOMBINANT VESICULAR STOMATITIS VIRUS (RVSV) BEARING THE SPIKE GLYCOPROTEIN S OF SARS-COV-2 AND USES THEREOF
(FR) VIRUS DE LA STOMATITE VÉSICULAIRE DE RECOMBINAISON INFECTIEUX (RVSV) PORTANT LA GLYCOPROTÉINE DE SPICULE S DU SRAS-COV-2 ET SES UTILISATIONS
Abstract
(EN) Provided herein are recombinant vesicular stomatitis virus (rVSV) or rVSV vector comprising nucleic acid encoding the spike glycoprotein S of SARS-COV-2, compositions comprising such vectors or viruses, as well as screening methods, diagnostic methods, prophylactic and therapeutic methods using such vectors or viruses.
(FR) L'invention concerne un virus de la stomatite vésiculaire de recombinaison (rVSV) ou un vecteur rVSV comprenant des acides nucléiques codant pour la glycoprotéine de spicule S du SRAS-COV-2, des compositions comprenant de tels vecteurs ou virus, ainsi que des procédés de criblage, des procédés diagnostiques, des procédés prophylactiques et thérapeutiques utilisant de tels vecteurs ou virus.
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