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1. WO2022010828 - PLASMA KALLIKREIN INHIBITORS

Publication Number WO/2022/010828
Publication Date 13.01.2022
International Application No. PCT/US2021/040420
International Filing Date 06.07.2021
IPC
A61K 47/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
02Inorganic compounds
A61K 47/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
12Carboxylic acids; Salts or anhydrides thereof
A61K 47/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • SHEARN-NANCE, Galen Paul [US]/[US] (US)
  • HICKS, Jacqueline, D. [US]/[US] (US)
  • KUANG, Rongze [US]/[US] (US)
  • SINZ, Christopher, J. [US]/[US] (US)
  • LOMBARDO, Matthew, J. [US]/[US] (US)
  • LOPEZ, Jovan Alexander [US]/[US] (US)
  • MERCHANT, Rohan [IN]/[US] (US)
  • SHARP, Phillip Patrick [AU]/[US] (US)
  • WU, Zhicai [US]/[US] (US)
  • ZHAO, Zhiqiang [US]/[US] (US)
  • CHENG, Alan, C. [US]/[US] (US)
  • YANG, Song [CN]/[US] (US)
  • BAO, Jianming [US]/[US] (US)
  • TIAN, Maoqun [CN]/[US] (US)
Inventors
  • HICKS, Jacqueline, D.
  • KUANG, Rongze
  • SINZ, Christopher, J.
  • LOMBARDO, Matthew, J.
  • LOPEZ, Jovan Alexander
  • MERCHANT, Rohan
  • SHARP, Phillip Patrick
  • WU, Zhicai
  • ZHAO, Zhiqiang
  • CHENG, Alan, C.
  • YANG, Song
  • BAO, Jianming
  • TIAN, Maoqun
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
63/050,22010.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PLASMA KALLIKREIN INHIBITORS
(FR) INHIBITEURS DE LA KALLICRÉINE PLASMATIQUE
Abstract
(EN) The present invention provides a compound of Formula (I), and pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing one or more disease states that could benefit from inhibition of plasma kallikrein, including hereditary angioedema, uveitis, posterior uveitis, wet age related macular edema, diabetic macular edema, diabetic retinopathy and retinal vein occlusion. The compounds are selective inhibitors of plasma kallikrein.
(FR) La présente invention concerne un composé représenté par la formule (I) et des compositions pharmaceutiques comprenant un ou plusieurs desdits composés, et des procédés d'utilisation desdits composés pour traiter ou prévenir un ou plusieurs états pathologiques qui pourraient bénéficier de l'inhibition de la kallicréine plasmatique, y compris l'angio-œdème héréditaire, l'uvéite, l'uvéite postérieure, l'œdème maculaire humide lié à l'âge, l'œdème maculaire diabétique, la rétinopathie diabétique et l'occlusion de la veine rétinienne. Lesdits composés sont des inhibiteurs sélectifs de la kallicréine plasmatique.
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