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1. WO2022010220 - NOVEL TRANSPLANTATION CELLS HAVING REDUCED IMMUNOGENICITY

Publication Number WO/2022/010220
Publication Date 13.01.2022
International Application No. PCT/KR2021/008554
International Filing Date 06.07.2021
IPC
C12N 15/113 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12N 15/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
C12N 9/22 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
C07K 14/74 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
74Major histocompatibility complex (MHC)
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
Applicants
  • 주식회사 지씨쎌 GC CELL CORPORATION [KR]/[KR]
Inventors
  • 김현아 KIM, Hyun Ah
  • 김승민 KIM, Seung Min
  • 허정현 HER, Jung Hyun
  • 조성림 CHO, Sunglim
  • 김효진 KIM, Hyojin
  • 임호용 LIM, Hoyong
  • 조성유 CHO, Sungyoo
  • 황유경 HWANG, Yu Kyeong
Agents
  • 파도특허법인(유한) PADO IP LAW PLLC
Priority Data
10-2020-008274806.07.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) NOVEL TRANSPLANTATION CELLS HAVING REDUCED IMMUNOGENICITY
(FR) NOUVELLES CELLULES DE TRANSPLANTATION AYANT UNE IMMUNOGÉNICITÉ RÉDUITE
(KO) 면역원성이 감소된 신규한 이식용 세포
Abstract
(EN) The present invention relates to a composition for suppressing immunogenicity in mammalian cells, and a method for preparing mammalian cells having low immunogenicity by using same. The present invention relates to cells to undergo allogeneic transplantation for a therapeutic purpose, such as stem cells or immunocytes, the cells being effectively usable as an efficient cell therapeutic agent having, in the body of a recipient, minimized immunorejection and activity that is maintained for a long time.
(FR) La présente invention concerne une composition pour supprimer l'immunogénicité dans des cellules de mammifère et un procédé de préparation de cellules de mammifère ayant une faible immunogénicité à l'aide de celle-ci. La présente invention concerne des cellules destinées à subir une transplantation allogénique à des fins thérapeutiques, tels que des cellules souches ou des immunocytes, les cellules pouvant être efficacement utilisées comme agent thérapeutique cellulaire efficace ayant, dans le corps d'un receveur, un immunorejet minimisé et une activité maintenue pendant une longue période.
(KO) 본 발명은 포유류 세포의 면역원성 저해용 조성물 및 이를 이용한 저면역원성 포유류 세포의 제조방법에 관한 것이다. 본 발명은 줄기세포나 면역세포 등 질환의 치료 목적으로 동종이식(allogeneic transplantation)되는 세포에 있어서, 수혜자의 체내에서 면역거부반응이 최소화되면서도 장기간 활성이 유지되는 효율적인 세포 치료제로 유용하게 이용될 수 있다.
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