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1. WO2022010219 - COMPOSITION FOR AMELIORATING PULMONARY FIBROSIS USING 4',6,7-TRIMETHOXYISOFLAVONE AND CATECHOL

Publication Number WO/2022/010219
Publication Date 13.01.2022
International Application No. PCT/KR2021/008552
International Filing Date 06.07.2021
IPC
A61K 31/352 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 43/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
A23L 33/10 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
Applicants
  • 주식회사 에이켐바이오 A-CHEMBIO CO.,LTD [KR]/[KR]
Inventors
  • 조문제 CHO, Moon Jae
  • 김영미 KIM, Young Mee
  • 손봉조 SON, Bong Jo
Agents
  • 특허법인 태웅 TW INTERNATIONAL PATENT AND LAW FIRM
Priority Data
10-2020-008422508.07.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR AMELIORATING PULMONARY FIBROSIS USING 4',6,7-TRIMETHOXYISOFLAVONE AND CATECHOL
(FR) COMPOSITION POUR SOULAGER LA FIBROSE PULMONAIRE À L'AIDE DE 4',6,7-TRIMÉTHOXYISOFLAVONE ET DE CATÉCHOL
(KO) 4',6,7-트리메톡시이소플라본과 카테콜을 이용한 폐섬유화증 개선용 조성물
Abstract
(EN) The present invention relates to a composition for ameliorating pulmonary fibrosis using 4',6,7-trimethoxyisoflavone and catechol (1,2-dihydroxybenzene) which have no cytotoxicity, and inhibit the TGF-β1 signaling pathway and thus have EMT inhibitory activity.
(FR) La présente invention concerne une composition pour soulager la fibrose pulmonaire à l'aide de 4',6,7-triméthoxyisoflavone et de catéchol (1,2-dihydroxybenzène), qui ne présentent pas de cytotoxicité, et inhibent la voie de signalisation du TGF-β1 et ont ainsi une activité inhibitrice d'EMT.
(KO) 본 발명은 본 발명은 세포독성이 없으면서 TGF-β1 신호 전달 경로를 억제하여 EMT 억제하는 활성을 가지는 4',6,7-트리메톡시이소플라본(4',6,7-trimethoxyisoflavone)와 카테콜(Catechol, 1,2-dihydroxybenzene)를 이용한 폐섬유화증 개선용 조성물을 개시한다.
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