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1. WO2022010169 - METHOD FOR PREDICTING AND IMPROVING TREATMENT RESPONSE TO INTESTINAL MICROBIOME-BASED CANCER IMMUNOTHERAPY AND METHOD FOR SCREENING FOR CANDIDATE PREBIOTICS

Publication Number WO/2022/010169
Publication Date 13.01.2022
International Application No. PCT/KR2021/008284
International Filing Date 30.06.2021
IPC
C12Q 1/689 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6888for detection or identification of organisms
689for bacteria
C12Q 1/6869 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6869Methods for sequencing
A61K 35/741
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
Applicants
  • 연세대학교 산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR]/[KR]
Inventors
  • 이인석 LEE, In Suk
  • 하상준 HA, Sang Jun
  • 김찬영 KIM, Chan Yeong
  • 김혜련 KIM, Hye Ryun
  • 안병철 AHN, Beung Chul
Agents
  • 특허법인 인벤싱크 INVENSYNC INTELLECTUAL PROPERTY GROUP
Priority Data
10-2020-008299406.07.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) METHOD FOR PREDICTING AND IMPROVING TREATMENT RESPONSE TO INTESTINAL MICROBIOME-BASED CANCER IMMUNOTHERAPY AND METHOD FOR SCREENING FOR CANDIDATE PREBIOTICS
(FR) PROCÉDÉ DE PRÉVISION ET D'AMÉLIORATION DE LA RÉPONSE DE TRAITEMENT D'IMMUNOTHÉRAPIE ANTICANCÉREUSE BASÉE SUR LE MICROBIOME INTESTINAL ET PROCÉDÉ DE CRIBLAGE DE PRÉBIOTIQUES CANDIDATS
(KO) 장내 미생물 기반 면역 항암 요법의 치료 반응 예측과 향상 방법 및 후보 프리바이오틱스 스크리닝 방법
Abstract
(EN) Provided are: a method for predicting a treatment response to cancer immunotherapy, the method comprising a step of evaluating, from feces isolated from a patient, the enrichment of a strain of the order TANB77 according to GTDB phylogenetic classification or taxa belonging to the order TANB77, and a step of predicting a treatment response of the patient to cancer immunotherapy on the basis of the enrichment of the order TANB77 or the taxa; a probiotics composition for improving a treatment response; a fecal microbiota transplantation composition; and a method for screening for candidate prebiotics by using same..
(FR) L'invention concerne : un procédé de prévision d'une réponse à un traitement d'immunothérapie anticancéreuse, le procédé comprenant une étape d'évaluation, sur des selles isolées à partir d'un patient, de l'enrichissement d'une souche de l'ordre TANB77 selon la classification phylogénétique GTDB ou d'un taxon appartenant à l'ordre TANB77, et une étape de prévision d'une réponse au traitement du patient par une immunothérapie anticancéreuse sur la base de l'enrichissement de l'ordre TANB77 ou du taxon ; une composition de probiotiques destinée à améliorer une réponse au traitement ; une composition de transplantation de microbiote fécal ; et un procédé de criblage de prébiotiques candidats l'employant.
(KO) 환자로부터 분리된 분변에 대하여, GTDB 계통 분류에 따른 TANB77 목 (order), 상기 TANB77 목 (order) 에 속하는 분류군 (taxa)의 균주의 풍부도 (enrichment) 를 평가하는 단계, 및 상기 TANB77 목, 또는 상기 분류군의 풍부도에 기초하여, 환자에 대한 면역 항암 요법에 대한 치료 반응을 예측하는 단계를 포함하는 면역 항암 요법의 치료 반응에 대한 예측 방법과 치료 반응을 향상시키기 위한 프로바이오틱스 조성물, 분변 미생물군 이식용 조성물 및 이를 이용한 후보 프리바이오틱스 스크리닝 방법이 제공된다.
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