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1. WO2022009988 - METHOD FOR DETECTING SEVERITY OF ATOPIC DERMATITIS

Publication Number WO/2022/009988
Publication Date 13.01.2022
International Application No. PCT/JP2021/025988
International Filing Date 09.07.2021
IPC
C12Q 1/6813 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6813Hybridisation assays
C12N 15/11 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
C12Q 1/6883 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/53 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
Applicants
  • 花王株式会社 KAO CORPORATION [JP]/[JP]
Inventors
  • 高田 直人 TAKADA, Naoto
  • 桑野 哲矢 KUWANO, Tetsuya
  • 井上 高良 INOUE, Takayoshi
Agents
  • 特許業務法人アルガ特許事務所 THE PATENT CORPORATE BODY ARUGA PATENT OFFICE
Priority Data
2020-11904010.07.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR DETECTING SEVERITY OF ATOPIC DERMATITIS
(FR) MÉTHODE VISANT À DÉTECTER LE DEGRÉ DE GRAVITÉ DE LA DERMATITE ATOPIQUE
(JA) アトピー性皮膚炎の重症度の検出方法
Abstract
(EN) Provided are a marker for detecting the severity of atopic dermatitis and a method for detecting the severity of atopic dermatitis using said marker. The method for detecting the severity of atopic dermatitis in a subject includes a step for measuring, in a biological sample collected from the subject, the expression level of at least one gene, or the expression product thereof, selected from the group consisting of nine genes which are: CAPN1, NCOR2, PPP1R9B, PLP2, GRN, PPP1R12C, LOC146880, SLC31A1 and SYVN1.
(FR) L'invention concerne un marqueur visant à détecter le degré de gravité de la dermatite atopique et une méthode visant à détecter le degré de gravité de la dermatite atopique à l'aide dudit marqueur. Ladite méthode de détection du degré de gravité de la dermatite atopique chez un sujet comprend une étape de mesure, dans un échantillon biologique prélevé chez le sujet, du niveau d'expression d'au moins un gène, ou de son produit d'expression, choisi dans le groupe constitué par neuf gènes, à savoir : CAPN1, NCOR2, PPP1R9B, PLP2, GRN, PPP1R12C, LOC146880, SLC31A1 et SYVN1.
(JA) アトピー性皮膚炎の重症度を検出するためのマーカー、及び該マーカーを用いたアトピー性皮膚炎の重症度の検出方法を提供する。 被験者から採取された生体試料について、CAPN1、NCOR2、PPP1R9B、PLP2、GRN、PPP1R12C、LOC146880、SLC31A1及びSYVN1からなる9種の遺伝子群より選択される少なくとも1つの遺伝子又はその発現産物の発現レベルを測定する工程を含む、当該被験者におけるアトピー性皮膚炎の重症度の検出方法。
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