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1. WO2022009911 - METHOD FOR PRODUCING 1,3-BENZODIOXOLE DERIVATIVE

Publication Number WO/2022/009911
Publication Date 13.01.2022
International Application No. PCT/JP2021/025537
International Filing Date 07.07.2021
IPC
C07D 317/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
46condensed with one six-membered ring
C07D 405/12 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07C 67/307 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
30by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
307by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C07C 69/84 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
76Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
84of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
CPC
C07C 67/307
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
30by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
307by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C07C 69/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
76Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
84of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
C07D 317/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
317Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
08having the hetero atoms in positions 1 and 3
44ortho- or peri-condensed with carbocyclic rings or ring systems
46condensed with one six-membered ring
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Y02P 20/55
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
20Technologies relating to chemical industry
50Improvements relating to the production of bulk chemicals
55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Applicants
  • 第一三共株式会社 DAIICHI SANKYO COMPANY, LIMITED [JP]/[JP]
Inventors
  • 上田 剛 UEDA Tsuyoshi
  • 海谷 雄士 KAIYA Yuji
  • 内田 貴久 UCHIDA Takahisa
  • 今井 誠 IMAI Makoto
Agents
  • 石橋 公樹 ISHIBASHI Koki
  • 竹元 利泰 TAKEMOTO Toshiyasu
Priority Data
2020-11763908.07.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING 1,3-BENZODIOXOLE DERIVATIVE
(FR) PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ DE 1,3-BENZODIOXOLE
(JA) 1,3-ベンゾジオキソール誘導体の製造方法
Abstract
(EN) The present invention addresses the problem of providing a novel method for producing a 1,3-benzodioxole derivative. The method comprises a novel chlorination reaction of a benzene ring which gives a good yield and a small amount of impurities and is industrially useful. A novel chlorination reaction of a benzene ring which gives a good yield and a small amount of impurities and is industrially useful was found by use of sulfuryl chloride in a novel method for producing a 1,3-benzodioxole derivative, and thus the invention was completed.
(FR) La présente invention aborde le problème de l'obtention d'un nouveau procédé de production d'un dérivé de 1,3-benzodioxole. Le procédé comprend une nouvelle réaction de chloration d'un cycle benzène qui permet d'obtenir un rendement satisfaisant et une faible quantité d'impuretés et qui est utile industriellement. Une nouvelle réaction de chloration d'un cycle benzène qui permet d'obtenir un rendement satisfaisant et une faible quantité d'impuretés et qui est industriellement utile a été découverte par l'utilisation de chlorure de sulfuryle dans un nouveau procédé de production d'un dérivé de 1,3-benzodioxole, permettant ainsi de parachever l'invention.
(JA) 本発明の課題は、高収率で不純物が少なく工業的に有用な、ベンゼン環の新規なクロル化反応を包含する1,3-ベンゾジオキソール誘導体の新規な製造方法を提供することである。 1,3-ベンゾジオキソール誘導体の新規な製造方法において、塩化スルフリルを用いることで、高収率で不純物が少ない工業的に有用なベンゼン環の新規なクロル化反応を見出し、発明を完成させた。
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