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1. WO2022009894 - REMEDY FOR INFLAMMATORY DISEASES

Publication Number WO/2022/009894
Publication Date 13.01.2022
International Application No. PCT/JP2021/025496
International Filing Date 06.07.2021
IPC
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A61P 43/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
C07K 14/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12N 15/12 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • 学校法人常翔学園 JOSHO GAKUEN EDUCATIONAL FOUNDATION [JP]/[JP]
  • 国立大学法人 鹿児島大学 KAGOSHIMA UNIVERSITY [JP]/[JP]
  • 学校法人久留米大学 KURUME UNIVERSITY [JP]/[JP]
Inventors
  • 川原 幸一 KAWAHARA, Koichi
  • 中富 康太 NAKATOMI, Kota
  • 丸山 征郎 MARUYAMA, Ikuro
  • 菊池 清志 KIKUCHI, Kiyoshi
Agents
  • 庄司隆 SHOJI, Takashi
  • 資延由利子 SUKENOBU, Yuriko
  • 大杉卓也 OHSUGI, Takuya
  • 庄司 晃 SHOJI, Akira
Priority Data
2020-11810108.07.2020JP
Publication Language Japanese (ja)
Filing Language Japanese (JA)
Designated States
Title
(EN) REMEDY FOR INFLAMMATORY DISEASES
(FR) TRAITEMENT DE MALADIES INFLAMMATOIRES
(JA) 炎症性疾患治療剤
Abstract
(EN) Provided is a novel remedy for inflammatory diseases or a novel suppressant against the production of inflammatory cytokines. The present invention is a remedy for inflammatory diseases or a suppressant against the production of inflammatory cytokines that contains, as an active ingredient, a substance that directly or indirectly inhibits interaction between damage-associated molecular patterns (DAMPs) and receptors therefor. According to this remedy for inflammatory diseases or suppressant against the production of inflammatory cytokines, the expression of inflammatory cytokines such as TNFα, IL-6, and IL-8 is suppressed due to the substance that serves as the active ingredient bonding to MD-2 and/or any selected from among nucleophosmin (NPM), histone H2A, histone H2B, histone H3, and histone H4 and inhibiting transmission of signals mediated by MD-2/TLR4 of DAMPs.
(FR) L'invention concerne un nouveau remède pour des maladies inflammatoires ou un nouveau suppresseur contre la production de cytokines inflammatoires. La présente invention concerne un remède pour des maladies inflammatoires ou un suppresseur contre la production de cytokines inflammatoires qui contient, en tant que principe actif, une substance qui inhibe directement ou indirectement l'interaction entre des motifs moléculaires associés aux dommages (DAMPs)) et des récepteurs correspondants. Selon ce remède pour des maladies inflammatoires ou un suppresseur contre la production de cytokines inflammatoires, l'expression de cytokines inflammatoires telles que TNFα, IL -6, et IL -8 est supprimée en raison de la substance qui sert de principe actif se liant à MD -2 et/ou à un élément quelconque choisi parmi la nucléophosmine (NPM), l'histone H2A, l'histone H2B, l'histone H3, et l'histone H4 et l'inhibition de la transmission de signaux médiés par MD-2/TLR4 des DAMPs.
(JA) 新規な炎症性疾患治療剤又は炎症性サイトカイン産生抑制剤を提供する。ダメージ関連分子パターン(DAMPs)とその受容体との相互作用を、直接的又は間接的に阻害する物質を有効成分として含有する炎症性疾患治療剤又は炎症性サイトカイン産生抑制剤による。本発明の炎症性疾患治療剤又は炎症性サイトカイン産生抑制剤によれば、有効成分としての物質がヌクレオフォスミン(NPM)、ヒストンH2A、ヒストンH2B、ヒストンH3及びヒストンH4より選択されるいずれか及び/又はMD-2に結合し、DAMPsのTLR4/MD-2を媒介するシグナル伝達を阻害することで、TNFα、IL-6及びIL-8等の炎症性サイトカインの発現を抑制する。
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