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1. WO2022009212 - TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS mTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE

Publication Number WO/2022/009212
Publication Date 13.01.2022
International Application No. PCT/IL2021/050842
International Filing Date 08.07.2021
IPC
A61K 31/198 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants
  • TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD. [IL]/[IL]
  • RAMBAM MED-TECH LTD. [IL]/[IL]
Inventors
  • LIVNEH, Ido
  • COHEN-KAPLAN, Victoria
  • CIECHANOVER, Aaron
  • GOLDHIRSH, Gilad
  • ZOHAR, Yaniv
  • LAVI, Noa
  • FABRE, Bertrand Francois
Agents
  • ZRIHAN-LICHT, Sheila
Priority Data
62/705,66809.07.2020US
63/147,88810.02.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TYROSINE, TRYPTOPHAN AND PHENYLALANINE AS mTOR AGONISTS MEDIATING PROTEASOME DYNAMICS, COMPOSITIONS, METHODS AND USES THEREOF IN THERAPY, AND PROGNOSTIC METHODS FOR DRUG-RESISTANCE
(FR) TYROSINE, TRYPTOPHANE ET PHÉNYLALANINE UTILISÉS EN TANT QU'AGONISTES MTOR MÉDIANT LA DYNAMIQUE DU PROTÉASOME, COMPOSITIONS, MÉTHODES ET UTILISATIONS DE CEUX-CI EN THÉRAPIE, ET MÉTHODES DE PRONOSTIC CONCERNANT LA PHARMACORÉSISTANCE
Abstract
(EN) The present disclosure provides mTOR agonists that selectively modulate proteasome dynamics, compositions, methods and uses thereof for modulation of stress-induced proteasome dynamics and related pathological conditions. The present disclosure specifically provides therapeutic methods for treating disorders associated with cytosolic accumulation of the proteasome. The invention further provides prognostic methods for detection and monitoring drug resistant cancers, as well as methods for screening for modulators of proteasome dynamics.
(FR) La présente invention concerne des agonistes mTOR qui modulent sélectivement la dynamique du protéasome, des compositions, des méthodes et des utilisations de ceux-ci pour la modulation de la dynamique du protéasome induite par le stress et des états pathologiques associés. La présente invention concerne spécifiquement des méthodes thérapeutiques de traitement de troubles associés à l'accumulation cytosolique du protéasome. L'invention concerne en outre des méthodes de pronostic pour la détection et la surveillance de cancers pharmacorésistants, ainsi que des méthodes de criblage de modulateurs de la dynamique du protéasome.
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