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1. WO2022009182 - CELL BASED METHOD FOR DETERMINATION OF BOTULINUM TOXIN POTENCY BASED ON WESTERN BLOTTING

Publication Number WO/2022/009182
Publication Date 13.01.2022
International Application No. PCT/IB2021/056210
International Filing Date 10.07.2021
IPC
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/94 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
94involving narcotics
G01N 33/561 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
558using diffusion or migration of antigen or antibody
561Immunoelectrophoresis
C12Q 1/37 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
34involving hydrolase
37involving peptidase or proteinase
Applicants
  • GALDERMA HOLDING SA [CH]/[CH]
Inventors
  • LEKHOLM, Emilia
  • JACOBSON, Sara
  • HELLSTEN, Sofie
  • FREDRIKSSON, Robert
  • DO, Anh-Tri
Priority Data
63/050,46110.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CELL BASED METHOD FOR DETERMINATION OF BOTULINUM TOXIN POTENCY BASED ON WESTERN BLOTTING
(FR) PROCÉDÉ À BASE DE CELLULES POUR LA DÉTERMINATION DE LA PUISSANCE DE LA TOXINE BOTULIQUE BASÉE SUR BUVARDAGE DE WESTERN
Abstract
(EN) Described are cell-based methods for detecting botulinum neurotoxin (BoNT) potency and/or activity in the absence of LD50 assays that rely upon large numbers of laboratory animals.
(FR) L'invention concerne des procédés à base de cellules pour détecter la puissance et/ou l'activité de la neurotoxine botulique (BoNT) en l'absence de dosages de LD50 qui reposent sur de grands nombres d'animaux de laboratoire.
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