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1. WO2022009165 - COMPOSITIONS AND METHODS USEFUL FOR THE PREVENTION AND/OR TREATMENT OF DISEASE IN MAMMALS

Publication Number WO/2022/009165
Publication Date 13.01.2022
International Application No. PCT/IB2021/056179
International Filing Date 09.07.2021
IPC
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 38/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
18Growth factors; Growth regulators
A61P 31/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
Applicants
  • NTULI, Thembalihle Fikile [ZA]/[ZA]
Inventors
  • SMIT, Michelle Olga Patricia Giesteira Da Silva
Agents
  • AJ RABIE ATTORNEYS
Priority Data
2020/0385009.07.2020ZA
2020/0400809.07.2020ZA
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS USEFUL FOR THE PREVENTION AND/OR TREATMENT OF DISEASE IN MAMMALS
(FR) COMPOSITIONS ET PROCÉDÉS UTILES POUR LA PRÉVENTION ET/OU LE TRAITEMENT DE MALADIE CHEZ DES MAMMIFÈRES
Abstract
(EN) Novel methods and pharmaceutical composition or medicaments are described for protecting a subject against, or treating a subject suffering from, disease characterised by viral infection and/or diseases associated with immune system disorder and/or viral cancers, by raising the levels of Ksp37 in the blood plasma of the subject to a therapeutically effective concentration level. According to the invention, a therapeutically effective amount of one or more of; a clinically modified or genetically engineered Ksp37 protein and/or proteins having a molecular weight in the range ranging from 24 kDa to 45 kDa, and/or a vector encoded with a KSP37 gene which will translate to a Ksp37 protein and/or proteins having a molecular weight in the range ranging from 24 kDa to 45 kDa, and/or a polar compound are administered to a subject.
(FR) La présente invention concerne de nouveaux procédés et une composition pharmaceutique ou des médicaments décrits pour la protection d’un sujet contre, ou le traitement d’un sujet souffrant de, une maladie caractérisée par l’infection virale et/ou des maladies associées à un trouble du système immunitaire et/ou des cancers d’origine virale, en élevant les niveaux de Ksp37 dans le plasma sanguin du sujet à un niveau de concentration thérapeutiquement efficace. Selon l’invention, une quantité thérapeutiquement efficace d’un ou plusieurs parmi : une protéine Ksp37 cliniquement modifiée ou génétiquement modifiée et/ou des protéines ayant un poids moléculaire situé dans la plage s’étendant de 24 kDa à 45 kDa, et/ou un vecteur codé avec un gène KSP37 qui sera traduit en une protéine Ksp37 et/ou des protéines ayant un poids moléculaire situé dans la plage s’étendant de 24 kDa à 45 kDa, et/ou un composé polaire sont administrés à un sujet.
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