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1. WO2022009034 - CARBON-ENCAPSULATED MYCOLIC ACID ANTIGENS AS SIMPLE AND LOW-COST ELECTROCHEMICAL IMMUNOSENSORS FOR ACTIVE TUBERCULOSIS

Publication Number WO/2022/009034
Publication Date 13.01.2022
International Application No. PCT/IB2021/055906
International Filing Date 01.07.2021
IPC
G01N 33/543 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/551 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
551the carrier being inorganic
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Applicants
  • UNIVERSITY OF PRETORIA [ZA]/[ZA]
Inventors
  • OZOEMENA, Kenneth, Ikechukwu
  • MATHEBULA, Nsovo, Samuel
Agents
  • RUPNARAIN, Charleen
Priority Data
2020/0413007.07.2020ZA
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CARBON-ENCAPSULATED MYCOLIC ACID ANTIGENS AS SIMPLE AND LOW-COST ELECTROCHEMICAL IMMUNOSENSORS FOR ACTIVE TUBERCULOSIS
(FR) ANTIGÈNES D'ACIDE MYCOLIQUE ENCAPSULÉS DANS DU CARBONE EN TANT QU'IMMUNOCAPTEURS ÉLECTROCHIMIQUES SIMPLES ET À FAIBLE COÛT POUR LA TUBERCULOSE ACTIVE
Abstract
(EN) The invention is directed at a method of encapsulating mycolic acid antigen in carbon, wherein carbon and mycolic acid antigen are dissolved in solution, the solution is ultrasonicated, and dried. The invention is also directed to a carbon-encapsulated mycolic acid antigen produced by this method for use as an electrochemical immunosensor for detection of tuberculosis by detecting presence of mycolic acid antibodies in a serum sample.
(FR) L'invention concerne un procédé d'encapsulation d'un antigène d'acide mycolique dans du carbone, selon lequel le carbone et l'antigène d'acide mycolique sont dissous en solution, la solution est soumise à ultrasons et séchée. L'invention concerne également un antigène d'acide mycolique encapsulé dans du carbone produit par ce procédé pour une utilisation en tant qu'immunocapteur électrochimique pour la détection de la tuberculose par la détection de la présence d'anticorps d'acide mycolique dans un échantillon de sérum.
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