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1. WO2022008935 - METHOD FOR PRODUCING GENETICALLY MODIFIED CELLS

Publication Number WO/2022/008935
Publication Date 13.01.2022
International Application No. PCT/GB2021/051775
International Filing Date 09.07.2021
IPC
C12N 9/22 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
16acting on ester bonds (3.1)
22Ribonucleases
C12N 15/10 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
Applicants
  • HORIZON DISCOVERY LIMITED [GB]/[GB]
Inventors
  • LAMBOURNE, John
  • PORRECA, Immacolate
Agents
  • STRATAGEM IPM LIMITED
Priority Data
2010689.410.07.2020GB
2015204.725.09.2020GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PRODUCING GENETICALLY MODIFIED CELLS
(FR) PROCÉDÉ DE PRODUCTION DE CELLULES GÉNÉTIQUEMENT MODIFIÉES
Abstract
(EN) A method for producing genetically engineered immune cells, e.g. T cells, or iPSCs which uses an RNA-scaffold mediated base editing system. The method enables precise modifications to be made to the genome whilst minimizing the possibility of off-target effects, making the method particularly suitable for therapeutic applications.
(FR) L'invention concerne un procédé de production de cellules immunitaires génétiquement modifiées, par ex. des lymphocytes T, ou des iPSC qui utilisent un système d'édition de base à médiation par échafaudage d'ARN. Le procédé permet d'apporter des modifications précises au génome tout en réduisant au minimum la possibilité d'effets hors cible, ce qui rend le procédé particulièrement approprié pour des applications thérapeutiques.
Latest bibliographic data on file with the International Bureau