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1. WO2022008905 - METHOD OF VALIDATING THE SELECTIVITY OF ANTIBODIES FOR POST TRANSLATIONAL MODIFICATIONS

Publication Number WO/2022/008905
Publication Date 13.01.2022
International Application No. PCT/GB2021/051724
International Filing Date 07.07.2021
IPC
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
G01N 33/531 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
G01N 33/536 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
536with immune complex formed in liquid phase
Applicants
  • ABCAM PLC [GB]/[GB]
Inventors
  • WEINER, Michael
  • FERGUSON, Mary
  • KELLY, Meghan
  • LI, Xiaofeng
  • JONES, Kezzia
Agents
  • BOULT WADE TENNANT, LLP
Priority Data
2012722.114.08.2020GB
63/048,78007.07.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF VALIDATING THE SELECTIVITY OF ANTIBODIES FOR POST TRANSLATIONAL MODIFICATIONS
(FR) PROCÉDÉ DE VALIDATION DE LA SÉLECTIVITÉ D'ANTICORPS POUR DES MODIFICATIONS POST-TRANSDUCTIONNELLES
Abstract
(EN) The invention provides a method of analysing the ability of an antibody to bind to a target epitope comprising a post-translational modification within a protein of interest, by assaying the binding of said antibody to a surrogate antigen comprising the target epitope with the post-translational modification. Also provided are relates kits; and surrogate antigens, such as maltose binding protein tagged with the target epitope.
(FR) L'invention concerne un procédé d'analyse de la capacité d'un anticorps à se lier à un épitope cible comprenant une modification post-transductionnelle à l'intérieur d'une protéine d'intérêt, par dosage de la liaison dudit anticorps à un antigène de substitution comprenant l'épitope cible avec la modification post-transductionnelle. L'invention concerne également des kits et des antigènes de substitution, tels que la protéine de liaison au maltose marquée avec l'épitope cible.
Latest bibliographic data on file with the International Bureau