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1. WO2022008761 - ACTIVE SUBSTANCE AGAINST PROTOZOA

Publication Number WO/2022/008761
Publication Date 13.01.2022
International Application No. PCT/EP2021/069376
International Filing Date 12.07.2021
IPC
A61K 31/44 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
A61K 31/22 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61K 31/341 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
341not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
A61K 31/343 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
343condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
A61K 31/381 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
38having sulfur as a ring hetero atom
381having five-membered rings
A61K 31/435 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
Applicants
  • CHRISTIAN-ALBRECHTS-UNIVERSITÄT ZU KIEL [DE]/[DE]
Inventors
  • BEITZ, Eric
  • WALLOCH, Philipp
  • HENKE, Björn
Agents
  • TARUTTIS, Stefan
Priority Data
20185333.010.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ACTIVE SUBSTANCE AGAINST PROTOZOA
(FR) SUBSTANCE ACTIVE DIRIGÉE CONTRE DES PROTOZOAIRES
Abstract
(EN) The present invention relates to active substances against protozoa, especially against Plasmodium spp., e.g. against Plasmodium falciparum, Plasmodium vivax, P. malariae, P. ovale, P. knowlesi, against Toxoplasma spp., e.g. Toxoplasma gondii, against Entamoeba histolytica, against Naegleria fowleri, and relates to a method of treatment and/or prophylaxis of an infection by a protozoon. The active substances are suitable for use in the treatment of and/or for use in prophylaxis of an infection by a protozoon. The active substances have the advantage of having activity against wild-type protozoa, especially against Plasmodium spp. and against Toxoplasma spp. and against Entamoeba histolytica and against Naegleria fowleri, and of having activity also against a mutant of P. falciparum that has been identified as resistant against other anti-malarial active substances.
(FR) La présente invention concerne des substances actives dirigées contre des protozoaires, en particulier contre Plasmodium spp, par exemple contre Plasmodium falciparum, Plasmodium vivax, P. malariae, P. ovale, P. knowlesi, contre Toxoplasma spp., par exemple Toxoplasma gondii, contre Entamoeba histolytica, contre Naegleria fowleri, et concerne une méthode de traitement et/ou de prophylaxie d'une infection par un protozoaire. Les substances actives sont appropriées pour être utilisées dans le traitement et/ou dans la prophylaxie d'une infection par un protozoaire. Les substances actives ont l'avantage de présenter une activité dirigée contre des protozoaires de type sauvage, en particulier contre Plasmodium spp., contre Toxoplasma spp., contre Entamoeba histolytica et contre Naegleria fowleri, et de présenter une activité dirigée également contre un mutant de P. falciparum qui a été identifié comme résistant vis-à-vis d'autres substances actives antipaludiques.
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