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1. WO2022008705 - SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR

Publication Number WO/2022/008705
Publication Date 13.01.2022
International Application No. PCT/EP2021/069112
International Filing Date 09.07.2021
IPC
C07D 403/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
04directly linked by a ring-member-to-ring- member bond
A61P 11/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
02Nasal agents, e.g. decongestants
A61P 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61K 31/506 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
Applicants
  • GRÜNENTHAL GMBH [DE]/[DE]
Inventors
  • ALEN, Jo
  • JAKOB, Florian
  • KRÜGER, Sebastian
  • BARBIE, Philipp
Priority Data
20185024.509.07.2020EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SUBSTITUTED PYRROLIDINE AMINES AND AMIDES AS MEDIATOR OF THE GLUCOCORTOID RECEPTOR
(FR) PYRROLIDINE AMINES SUBSTITUÉES ET AMIDES EN TANT QUE MÉDIATEUR DU RÉCEPTEUR DE GLUCOCORTOÏDE
Abstract
(EN) The invention relates to compounds according to general formula (I) which act as modulators of the glucocorticoid receptor and can be used in the treatment and/or prophylaxis of disorders which are at least partially mediated by the glucocorticoid receptor.
(FR) L'invention concerne des composés de formule générale (I) qui agissent en tant que modulateurs du récepteur de glucocorticoïde et qui peuvent être utilisés dans le traitement et/ou la prophylaxie de troubles qui sont au moins partiellement médiés par le récepteur de glucocorticoïde.
Latest bibliographic data on file with the International Bureau